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Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors.
- J. Cryan, O. O'Leary, I. Lucki
- Psychology, BiologyProceedings of the National Academy of Sciences…
- 25 May 2004
Restoration of NE by using L-threo-3,4-dihydroxyphenylserine reinstated the behavioral effects of both desipramine and paroxetine in Dbh(-/-) mice, thus demonstrating that the reduced sensitivity to antidepressants is related to NE function, as opposed to developmental abnormalities resulting from chronic NE deficiency.
Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat
Automated tests for measuring the effects of antidepressants in mice
Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test
- O. O'Leary, Anita J. Bechtholt, J. Crowley, T. E. Hill, M. Page, I. Lucki
- Psychology, BiologyPsychopharmacology
- 21 February 2007
It is demonstrated that endogenous 5-HT synthesis mediates the behavioral effects of SSRIs, but not NRIs, in the TST, whereas disruption of the behavioraleffects of NRI and SSRI antidepressants required disruption of both catecholamine synthesis and vesicular storage and release mechanisms.
A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.
Towards translational rodent models of depression
The present review outlines the most commonly used models of depression and antidepressant drug-like activity and suggests several factors that should be considered when refining these models.
Adult Hippocampal Neurogenesis Is Regulated by the Microbiome
Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome.
- J. Pereira, K. Rea, Y. Nolan, O. O'Leary, T. Dinan, J. Cryan
- Psychology, BiologyAnnual review of psychology
- 6 January 2020
This review integrates the available data from animal and human studies on these three factors in the etiology and progression of depression and focuses on the processes by which this microbiota-immune-stress matrix may influence centrally mediated events and on possible therapeutic interventions to correct imbalances in this triune.
Distinguishing roles for norepinephrine and serotonin in the behavioral effects of antidepressant drugs.
The pattern of responses of presynaptic markers suggests that pharmacologic selectivity is maintained after chronic administration of many antidepressants, and it is also possible that compounds with dual actions at 5-HT and norepinephrine systems may be effective under circumstances in which selective antidepressants are ineffective.