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Reference distributions for the negative acute‐phase serum proteins, albumin, transferrin and transthyretin: A practical, simple and clinically relevant approach in a large cohort
Inflammation is associated with diverse clinical conditions accompanied by characteristic changes in serum levels of the acute‐phase proteins that can be used to stage the inflammatory process andExpand
Reference distributions for immunoglobulins A, G, and M: A practical, simple, and clinically relevant approach in a large cohort
TLDR
Using automated immunoassay values from 115,017 serum samples from northern New England patients to provide more reliable and comprehensive reference distributions for IgA, IgG, and IgM measurements enables interpretation of serum immunoglobulin measurements using a common unit (multiples of the median) that is independent of age or gender. Expand
Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature
TLDR
This meta‐analysis provides support for the reliability of the recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. Expand
Reference distributions for complement proteins C3 and C4: A practical, simple and clinically relevant approach in a large cohort
The two serum proteins of the complement cascade in the highest concentrations, C3 and C4, respond to various conditions in much the same manner as do other positive acute‐phase proteins. A majorExpand
Reference distributions for alpha2‐macroglobulin: A practical, simple and clinically relevant approach in a large cohort
TLDR
It is confirmed that α2M does not respond to acute phase drive in man, and values were expressed as multiples of the age‐ and gender‐specific median levels, the resulting distributions fitted a log‐Gaussian distribution well over a broad range. Expand
Reference distributions for the positive acute phase serum proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A practical, simple, and clinically relevant approach in a
Most clinical conditions are accompanied by corresponding changes in serum levels of some, if not all, of the acute phase proteins. While conditions that affect the acute phase proteins are usuallyExpand
Reference distributions for the positive acute phase proteins, α1‐acid glycoprotein (orosomucoid), α1‐antitrypsin, and haptoglobin: A comparison of a large cohort to the world’s literature
TLDR
A meta‐analysis provides support for the reference ranges of positive acute phase protein measurements, over their constrained age ranges, with their life‐long reference ranges and places them in the perspective of previous publications. Expand
Reference distributions for serum iron and transferrin saturation: a practical, simple, and clinically relevant approach in a large cohort
The principal considerations driving iron status evaluation are clinical concern for anemia and the possibility of iron‐storage disease. Most often, the circulating levels of transferrin (or totalExpand
Fine‐needle aspiration biopsy diagnosis of prostate carcinoma metastatic to the breast
TLDR
A 60-year-old man presented with a large right breast mass measuring 4 cm in greatest dimension and the double negativity for CK7 and CK20, in addition to the expression of prostate markers (PSA, P504S, AR) and the lack of breast markers (GCDFP15, mammaglobin, ER, and PR), supported the diagnosis of metastatic adenocarcinoma of prostatic origin. Expand
Reference distributions for α2‐macroglobulin: A comparison of a large cohort to the world's literature
TLDR
A meta‐analysis provides support for the reference ranges of serum alpha2‐macroglobulin and places them in the perspective of previous publications, and identifies publications reporting reference intervals that meet the criteria used in prior studies. Expand
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