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Estimating divergence times in large molecular phylogenies
Molecular dating of species divergences has become an important means to add a temporal dimension to the Tree of Life. Increasingly larger datasets encompassing greater taxonomic diversity areExpand
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exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://exrna-atlas.org). TheExpand
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A Protocol for Diagnosing the Effect of Calibration Priors on Posterior Time Estimates: A Case Study for the Cambrian Explosion of Animal Phyla.
We present a procedure to test the effect of calibration priors on estimated times, which applies a recently developed calibration-free approach (RelTime) method that produces relative divergenceExpand
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Prospects for building large timetrees using molecular data with incomplete gene coverage among species.
Scientists are assembling sequence data sets from increasing numbers of species and genes to build comprehensive timetrees. However, data are often unavailable for some species and gene combinations,Expand
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SYNTHETIC TRANSMEMBRANE CHANNELS : FUNCTIONAL CHARACTERIZATION USING SOLUBILITY CALCULATIONS, TRANSPORT STUDIES, AND SUBSTITUENT EFFECTS
Dibenzyldiaza-18-crown-6 (PhCH2〈N18N〉CH2Ph, 1), di(dodecyldiaza-18-crown-6 (C12H25〈N18N〉C12H25, 2), HOOC(CH2)11〈N18N〉(CH2)11COOH (3), 〈18N〉(CH2)12〈N18N〉(CH2)12〈N18〉 (4),Expand
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Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.
Hydraphile compounds are shown to be cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares favorably with other synthetic ionophores andExpand
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Phylogenetic placement of metagenomic reads using the minimum evolution principle
BackgroundA central problem of computational metagenomics is determining the correct placement into an existing phylogenetic tree of individual reads (nucleotide sequences of varying lengths, rangingExpand
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A tris(macrocycle) that exhibits H-bond-induced blockage of the cation channel faction in a phospholipid bilayer
An indole-terminated tris(macrocyclic) compound, designed to be a channel-former, is an effective carrier in bluk membranes but fails to function in a lipid bilayer owing to hydrogen bond formationExpand
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