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Nuclear Pore Complex Structure and Dynamics Revealed by Cryoelectron Tomography
Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze their structure in a close-to-life state, we studied transport-active, intact nuclei from Dictyostelium… Expand
The molecular architecture of lamins in somatic cells
The nuclear lamina is a fundamental constituent of metazoan nuclei. It is composed mainly of lamins, which are intermediate filament proteins that assemble into a filamentous meshwork, bridging the… Expand
Macromolecular Architecture in Eukaryotic Cells Visualized by Cryoelectron Tomography
- O. Medalia, Igor Weber, A. Frangakis, D. Nicastro, G. Gerisch, W. Baumeister
- Medicine, Biology
- 8 November 2002
Electron tomography of vitrified cells is a noninvasive three-dimensional imaging technique that opens up new vistas for exploring the supramolecular organization of the cytoplasm. We applied this… Expand
Snapshots of nuclear pore complexes in action captured by cryo-electron tomography
Nuclear pore complexes reside in the nuclear envelope of eukaryotic cells and mediate the nucleocytoplasmic exchange of macromolecules. Traffic is regulated by mobile transport receptors that target… Expand
Outcome of the First Electron Microscopy Validation Task Force Meeting
This Meeting Review describes the proceedings and conclusions from the inaugural meeting of the Electron Microscopy Validation Task Force organized by the Unified Data Resource for 3DEM… Expand
Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography.
- F. Förster, O. Medalia, N. Zauberman, W. Baumeister, D. Fass
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 29 March 2005
We used cryo-electron tomography in conjunction with single-particle averaging techniques to study the structures of frozen-hydrated envelope glycoprotein (Env) complexes on intact Moloney murine… Expand
The human nuclear pore complex as revealed by cryo-electron tomography.
Nuclear pore complexes (NPCs) are the sole passage through the nuclear envelope, connecting the cytoplasm to the nucleoplasm. These gigantic molecular machines, over 100 MDa in molecular weight,… Expand
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome
The COP9 signalosome (CSN) purified from human erythrocytes possesses kinase activity that phosphoryl ates proteins such as c‐Jun and p53 with consequence for their ubiquitin (Ub)‐dependent… Expand
Functional architecture of the nuclear pore complex.
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous translocation channels that allow the free… Expand
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
- Pekka Taimen, Katrin Pfleghaar, +9 authors R. Goldman
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 8 December 2009
Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the α-helical central rod domain required for the polymerization of… Expand