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High throughput artificial membrane permeability assay for blood-brain barrier.
The recent advances in high throughput screening for biological activities and combinatorial chemistry have greatly expanded the number of drug candidates. Rapid screening for BBB penetrationExpand
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Halogen chemistry of the red alga Asparagopsis
Abstract Ethanol extraction of fresh Asparagopsis taxiformis and A. armata, followed by pentane partition, results in the isolation of a series of halomethanes, among them MeI, CHCl3, and CCl4. UnderExpand
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Epibiosis of Marine Algae and Benthic Invertebrates: Natural Products Chemistry and Other Mechanisms Inhibiting Settlement and Overgrowth
This article reviews chemical and physical mechanisms by which non-motile marine invertebrates and marine algae inhibit the fouling of their surfaces. Inhibition of primary film formation (bacterial,Expand
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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
A bioassay guided approach was used to isolate two antitumor tetrahydroisoquinoline alkaloids, 3 and 4, from the marine ascidian Ecteinascidia turbinata. The structures of 3 and 4 were determinedExpand
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Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography-mass spectrometry.
  • E. Kerns, Li Di, +4 authors G. Carter
  • Medicine, Chemistry
  • Journal of chromatography. B, Analytical…
  • 5 July 2003
A method is described for the simultaneous profiling of sample lipophilicity, integrity, and purity. The method is rapid and is applicable to high throughput profiling of pharmaceutical properties inExpand
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Ptilomycalin A: a novel polycyclic guanidine alkaloid of marine origin
Identification par spectrometrie de masse d'un nouvel alcaloide guanidique d'origine marine (Eponge): la Ptilomycaline A
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Determination of rat oral bioavailability of soy-derived phytoestrogens using an automated on-column extraction procedure and electrospray tandem mass spectrometry.
In recent years, consumption of herbal supplements as an alternative to pharmaceutical drug therapy has increased. For example, with the health claims labeling which describes the link betweenExpand
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Isospongiadiol, a Cytotoxic and Antiviral Diterpene from a Caribbean Deep Water Marine Sponge, Spongia sp.
Spongiadiol, epispongiadiol, and isospongiadiol, a novel furanoditerpene with cytotoxic and antiviral activity, were isolated from a Caribbean deep water marine sponge, Spongia sp. Isospongiadiol wasExpand
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Halogen chemistry of the red alga Bonnemaisonia
Abstract Complete accounts of the natural products chemistry of Bonnemaisonia nootkana, B. asparagoides, B. hamifera and Trailliella intricata are described. In contrast to the chemistry of theExpand
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