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TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by acting as a GTPase-activatingExpand
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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
BACKGROUND In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle control, DNA repair, senescence,Expand
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Regulation of bone mass by Wnt signaling.
Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth, differentiation, function, and death. Considerable progress has been made in our understanding of theExpand
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Transcriptional regulation of gene expression during adipocyte differentiation.
Cell culture models (e.g. 3T3-L1 cells) have been developed for studying the process of adipocyte differentiation. Differentiation can be induced by adding insulin-like growth factor I,Expand
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Regulation of adipocyte development.
INTRODUCTION . . . • . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . . . • • . . . . . . . . • . • . . . . . . • 99 CELL CULTURE MODELS FOR ADIPOCYTE DEVELOPMENT . • • . . . . . . • . • .Expand
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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here weExpand
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The Role of C/EBP Genes in Adipocyte Differentiation*
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Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis of organisms and cells. The sterol regulatory element-binding protein (SREBP) transcription factorExpand
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Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for thisExpand
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Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues
Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipidExpand
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