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Neuronal replacement from endogenous precursors in the adult brain after stroke
In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease.Expand
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Inflammation is detrimental for neurogenesis in adult brain
New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area whereExpand
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Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke
Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been consideredExpand
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Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors and neurons from human embryonic stemExpand
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Direct conversion of human fibroblasts to dopaminergic neurons
Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Here we show that the same strategy can beExpand
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Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contributeExpand
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Seizures induce widespread upregulation of cystatin B, the gene mutated in progressive myoclonus epilepsy, in rat forebrain neurons
Loss of function mutations in the gene encoding the cysteine protease inhibitor, cystatin B (CSTB), are responsible for the primary defect in human progressive myoclonus epilepsy (EPM1). CSTBExpand
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Brain inflammation and adult neurogenesis: The dual role of microglia
In the adult mammalian brain, neurogenesis from neural stem/progenitor cells continues in two regions: the subgranular zone in the dentate gyrus and the subventricular zone lining the lateralExpand
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Cell replacement therapies for central nervous system disorders
In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair. Clinical trials in Parkinson's disease suggest that similar approaches may alsoExpand
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Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures.
Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situExpand
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