• Publications
  • Influence
Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
Results indicate that IFN- gamma mediates necrosis in the ilea of B6 mice after infection, whereas the same cytokine plays a critical role in the resistance of genetically resistant BALB/c mice. Expand
Ocular toxoplasmosis past, present and new aspects of an old disease
Current clinical understanding of OT including typical and atypical manifestations, patient characteristics which influence the course of disease and treatment options are discussed, and a brief outlook is given in which direction OT research should be headed in the future. Expand
Prevalence and risk factors of toxoplasmosis among pregnant women in Fortaleza, Northeastern Brazil.
Young women in northeastern Brazil living under poor socioeconomic conditions are at highest risk for acquiring infection with T. gondii, and oocyst contamination of water and soil must be addressed in future prevention strategies. Expand
Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Interleukin (IL)-23–mediated gelatinase A (matrixmetalloproteinase [MMP]-2) up-regulation in the ileum of infected mice protected mice from the development of T. gondii–induced immunopathology and suggested that these enzymes may be useful targets for treatment of intestinal inflammation. Expand
Immunology of Toxoplasma gondii
In the present review, parasitological, epidemiological, clinical, and molecular biological aspects of infection with T. gondii are introduced to set the stage for an in‐depth discussion of host immune responses. Expand
Molecular diagnosis of sepsis: New aspects and recent developments.
By shortening the time to pathogen identification and allowing for detection of organisms missed by blood culture, new molecular methods may provide clinical benefits for the management of patientsExpand
Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii1
Gram-negative bacteria, i.e., E. coli, aggravate pathogen-induced intestinal Th1-type immunopathology and may prove useful to study bacteria-host interactions in small intestinal inflammation and to test novel therapies based on modulation of gut flora. Expand
Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease?
  • O. Liesenfeld
  • Medicine
  • The Journal of infectious diseases
  • 15 February 2002
Findings indicate a Th1-type immunopathology, with parasite replication appearing to be involved in the first 3 days of infection, and massive necrosis of the villi and mucosal cells in the ilea is observed in C57BL/6 but not BALB/c mice. Expand
European Multicenter Study of the LIAISON Automated Diagnostic System for Determination of Toxoplasma gondii-Specific Immunoglobulin G (IgG) and IgM and the IgG Avidity Index
The LIAISON avidity assay is a valuable assay for the exclusion of recently acquired infection with T. gondii in pregnant women, and it decreases significantly the necessity for follow-up testing. Expand
Intracellular transport of Toxoplasma gondii through the blood–brain barrier
Results suggest that T. gondii modulates gene expression of brain endothelial cells to promote its own migration through the blood-brain barrier in a 'Trojan horse' manner. Expand