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IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information.
TLDR
The IrisPlex eye colour prediction test represents one of the first steps forward in the creation of a fully individualised EVC prediction system for future use in forensic DNA intelligence. Expand
Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications.
TLDR
The 13 most mutable Y-STRs are analyzed in an independent sample set and empirically proved their suitability for distinguishing close and distantly related males, expected to revolutionize Y-chromosomal applications in forensic biology. Expand
Correlation between Genetic and Geographic Structure in Europe
TLDR
Although Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations was investigated, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance, which provided evidence for a spatial continuity of genetic diversity in Europe. Expand
Signatures of Positive Selection in Genes Associated with Human Skin Pigmentation as Revealed from Analyses of Single Nucleotide Polymorphisms
TLDR
The data suggest that light skin colour is the derived state and is of independent origin in Europeans and Asians, whereas dark skin color seems of unique origin, reflecting the ancestral state in humans. Expand
Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages
TLDR
The present results suggest that the mtDNA found out of Africa might be the result of a maturation phase, presumably in the Middle East or eastern Africa, that led to haplogroups M and N, and subsequently expanded into Eurasia, yielding a geographically structured group of external branches of these two haplog groups in western and eastern Eurasia. Expand
Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific.
TLDR
Surprisingly, gradients in the frequency distribution of some NRY/mtDNA haplogroups across Polynesia and a gradual west-to-east decrease of overall Nry/mt DNA diversity are identified, providing evidence for a west- to-east direction of Polynesian settlements but also suggesting that Pacific voyaging was regular rather than haphazard. Expand
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
TLDR
The CYP2D6 diversity is far greater within than between populations and groups thereof, null or low-activity variants occur at high frequencies in various areas of the world, and linkage disequilibrium is lowest in Africa and highest in the Americas. Expand
Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry.
TLDR
It is shown that it is possible to reduce the amount of markers required for detecting continental population structure to only 10 single-nucleotide polymorphisms (SNPs), by applying a newly developed ascertainment algorithm to Affymetrix GeneChip Mapping 10K SNP array data that was obtained from samples of globally dispersed human individuals. Expand
A genomic history of Aboriginal Australia
TLDR
A population expansion in northeast Australia during the Holocene epoch associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama–Nyungan languages is inferred. Expand
Palaeogenetic evidence supports a dual model of Neolithic spreading into Europe
TLDR
A dual model of Neolithic spread is proposed: acculturation in Central Europe and demic diffusion in southern Europe and shows that the haplogroup composition of the Neolithic population is very similar to that found in modern populations from the Iberian Peninsula, suggesting a long-time genetic continuity. Expand
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