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- Publications
- Influence
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
- M. Dusseaux, Emmanuel Martin, +8 authors O. Lantz
- Biology, Medicine
- Blood
- 27 January 2011
Mucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are CD161(hi)IL-18Rα(+) and either… Expand
Antimicrobial activity of mucosal-associated invariant T cells
- L. Bourhis, Emmanuel Martin, +15 authors O. Lantz
- Biology, Medicine
- Nature Immunology
- 1 August 2010
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) α-chain and restriction by the… Expand
CD1 recognition by mouse NK1+ T lymphocytes.
- A. Bendelac, O. Lantz, M. E. Quimby, J. Yewdell, J. Bennink, R. Brutkiewicz
- Biology, Medicine
- Science
- 12 May 1995
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of… Expand
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
- O. Lantz, A. Bendelac
- Biology, Medicine
- The Journal of experimental medicine
- 1 September 1994
The mouse thymus contains a mature T cell subset that is distinguishable from the mainstream thymocytes by several characteristics. It is restricted in its usage of T cell receptor (TCR) V beta genes… Expand
The transcription factor PLZF directs the effector program of the NKT cell lineage.
- A. Savage, Michael G Constantinides, +5 authors A. Bendelac
- Biology, Medicine
- Immunity
- 19 September 2008
The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of… Expand
Stepwise Development of MAIT Cells in Mouse and Human
- E. Martin, E. Treiner, +12 authors O. Lantz
- Biology, Medicine
- PLoS biology
- 1 March 2009
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)α (iTCRα) chain and restriction by the nonpolymorphic class Ib major… Expand
Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes
- C. Théry, L. Duban, E. Segura, P. Véron, O. Lantz, S. Amigorena
- Chemistry, Biology
- Nature Immunology
- 11 November 2002
Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of… Expand
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
- M. Gold, S. Cerri, +15 authors D. Lewinsohn
- Biology, Medicine
- PLoS biology
- 1 June 2010
A first indication of the biological role of mucosal associated invariant T (MAIT) cells reveals that this discrete T cell subset is broadly reactive to bacterial infection. In particular MAIT cells… Expand
Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells
- A. Bendelac, R. Hunziker, O. Lantz
- Biology, Medicine
- The Journal of experimental medicine
- 1 October 1996
Natural Killer (NK)1.1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that are normally associated with the NK cell lineage of the innate immune… Expand
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells
Summary Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor… Expand