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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells.
The gut-liver homing characteristics, high expression of ABCB1, and ability to secrete interleukin-17 probably participate in the antibacterial properties of MAIT cells.
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
It is shown that T cells that express the canonical hVα7.2-Jα33 or mVα19-J α33 TCR rearrangement are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal-associated invariant T (MAIT) cells.
Antimicrobial activity of mucosal-associated invariant T cells
MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection and protect against infection by Mycobacterium abscessus or Escherichia coli.
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
The mouse thymus contains a mature T cell subset that is distinguishable from the mainstream thymocytes by several characteristics, and it is found that, whereas the beta chain V-D-J junctions are quite variable, a single invariant alpha chain V alpha 14-J281 is used by a majority of the TCRs.
Stepwise Development of MAIT Cells in Mouse and Human
MAIT cells are selected by MR1 in the thymus on a non-B non-T hematopoietic cell, and acquire a memory phenotype and expand in the periphery in a process dependent both upon B cells and the bacterial flora.
CD1 recognition by mouse NK1+ T lymphocytes.
- A. Bendelac, O. Lantz, M. E. Quimby, J. Yewdell, J. Bennink, R. Brutkiewicz
- 12 May 1995
In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific, providing evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes
- C. Théry, Livine Duban, E. Segura, P. Véron, O. Lantz, S. Amigorena
- BiologyNature Immunology
- 11 November 2002
It is found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo and may increase the number of DCs bearing a particular peptide, thus amplifying the initiation of primary adaptive immune responses.
The transcription factor PLZF directs the effector program of the NKT cell lineage.
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
A first indication of the biological role of mucosal associated invariant T (MAIT) cells reveals that this discrete T cell subset is broadly reactive to bacterial infection. In particular MAIT cells…