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Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action
TLDR
EGCG and delphinidin inhibit HCV entry by a new mechanism, i.e., alteration of the viral particle structure that impairs its attachment to the cell surface, inducing a bulge on the viral envelope.
Structural analysis of junctions formed between lipid membranes and several annexins by cryo-electron microscopy.
The (annexin II-p11)2 tetramer has been proposed to participate in exocytosis and several other members of the annexin superfamily have been reported to aggregate liposomes in vitro. In this context,
A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles.
TLDR
PE6400 abolishes the ceiling effect on transgene expression of increasing amounts of naked DNA and permits long-term expression of the beta-galactosidase reporter gene in immunologically tolerant transgenic rats, and provides a simple gene delivery system for skeletal and myocardial gene transfer.
The Motor Protein Myosin-X Transports VE-Cadherin along Filopodia To Allow the Formation of Early Endothelial Cell-Cell Contacts
TLDR
It is proposed that VE-cadherin trafficking along filopodia using myosin-X motor protein is a prerequisite for cell-cell junction formation, which may have functional consequences for endothelium repair in pathological settings.
The formation of supported lipid bilayers on silica nanoparticles revealed by cryoelectron microscopy.
TLDR
The nanoSLBs were found to follow faithfully the surface contours of the particles, information yet unavailable for SLB formation on planar solid substrates.
Tripartite assembly of RND multidrug efflux pumps
TLDR
The reconstitution of native Pseudomonas aeruginosa MexAB–OprM and Escherichia coli AcrAB–TolC tripartite Resistance Nodulation and cell Division (RND) efflux systems in a lipid nanodisc system is presented.
Two-dimensional crystallization on lipid layer: A successful approach for membrane proteins.
TLDR
This protocol for crystallizing membrane protein that is derived from the classical lipid-layer two-dimensional crystallization at the air/water interface is developed and represents a new promising alternative to conventional dialysis methods for membrane protein 2D crystallization, with the additional advantage of necessitating little purified protein.
Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer.
TLDR
The new nanostructured material, the structure of which clearly contrasted with that of lipoplexes and polyplexes, efficiently transferred reporter and therapeutic genes in skeletal and heart muscle in vivo.
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