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Spatiotemporal characteristics of astroglial death in the rat hippocampo‐entorhinal complex following pilocarpine‐induced status epilepticus
TLDR
Findings suggest that regional specific astroglial death/regeneration patterns may play an important role in the pathogenesis of temporal lobe epilepsy. Expand
Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase.
TLDR
The data indicate that mRNA expression of all three enzymes essential for vitamin B(6) metabolism is ubiquitous but is highly regulated at the level of transcription in a tissue-specific manner. Expand
Gastrodin decreases immunoreactivities of γ‐aminobutyric acid shunt enzymes in the hippocampus of seizure‐sensitive gerbils
TLDR
It is suggested that gastrodin may cause the elevation of GABA concentration by inhibiting the GABA shunt from the neuroanatomical viewpoint. Expand
Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy
TLDR
It is believed that it is worth considering new therapeutic approaches to epileptogenesis involving targeting the inactivation of microglia and protecting against astroglial loss, as well as altered morphological organization or the functionalities of astrocytes induced by status epilepticus. Expand
Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury.
TLDR
Results demonstrate that transduced Tat-GLO protein protects neuronal cells by inhibiting MG- and H2O2-mediated cytotoxicity in vitro and in vivo and suggest that Tat- GLO proteins could be useful as a therapeutic agent for various human diseases related to oxidative stress including brain diseases. Expand
Immunohistochemical studies of brain pyridoxine-5′-phosphate oxidase
TLDR
The finding that immunoreactive neurons in PNP oxidase were found in cerebellar cortex, hippocampus, amygdala, paraventricular nucleus, cerebral cortex and ependyma suggests that P NP oxidase may play an important role in the neuronal metabolism. Expand
Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats.
TLDR
Dietary cinnamate inhibits hepatic HMG-CoA reductase activity, resulting in lower hepatic cholesterol content, and suppresses lipid peroxidation via enhancement of hepatic antioxidant enzyme activities. Expand
Transduced Tat-SOD fusion protein protects against ischemic brain injury.
TLDR
The results suggest that Tat-SOD provides a strategy for therapeutic delivery in various hu-man diseases, including stroke, related to this anti-oxidant enzyme or to ROS. Expand
Transduced human PEP‐1–heat shock protein 27 efficiently protects against brain ischemic insult
TLDR
It is suggested that transduction of PEP‐1–HSP27 fusion protein provides a potential strategy for therapeutic delivery in various human diseases in which reactive oxygen species are implicated, including stroke. Expand
Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model
TLDR
Topical application of PEP-1-FK506BP to BTX-A-induced mouse model markedly inhibited expression levels of pro-inflammatory cytokines such as interleukin-1β (IL-1 β), tumor necrosis factor-α (TNF-α) and macrophage inhibitory factor (MIF) in corneal and conjunctival epithelium. Expand
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