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A purinergic component of the excitatory postsynaptic current mediated by P2X receptors in the CA1 neurons of the rat hippocampus
The pyramidal neurons in the CA1 area of hippocampal slices from 17‐ to 19‐day‐old rats have been investigated by means of patch clamp. Excitatory postsynaptic currents (EPSCs) were elicited byExpand
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The ASICs: Signaling molecules? Modulators?
  • O. Krishtal
  • Medicine, Psychology
  • Trends in Neurosciences
  • 1 September 2003
Acid-sensing ionic channels (ASICs) are almost ubiquitous in the mammalian nervous system, both at the periphery and in the brain. Strong evidence for the physiological function of these moleculesExpand
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Acid sensing ionic channels: modulation by redox reagents.
Acid-sensing ion channels (ASICs) are widely expressed in mammalian sensory neurons and supposedly play a role in nociception and acid sensing. In the course of functioning the redox status of theExpand
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P2X3 receptor gating near normal body temperature
P2X3 purinoreceptors expressed in mammalian sensory neurons are involved in nociception, mechanosensory transduction, and temperature sensation. Homomeric P2X3 receptors desensitize rapidly (<500 msExpand
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P2X receptors in sensory neurons co‐cultured with cancer cells exhibit a decrease in opioid sensitivity
Opioids are known to control the activity of P2X receptors in the sensory neurons of rats. These receptors are important in persistent pain signaling. However, there are extremely severe pain states,Expand
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Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum.
Despite almost forty years of widespread use of antidepressant drugs, their mode of action is still unknown. Hyperforin, a phloroglucinol derivative, is a major pharmacologically and therapeuticallyExpand
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Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors.
When performed at increased external [Ca2+]/[Mg2+] ratio (2.5 mM/0.5 mM), temporary block of A1 adenosine receptors in hippocampus [by 8-cyclopentyltheophylline (CPT)] leads to a dramatic andExpand
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Receptor for protons: First observations on Acid Sensing Ion Channels
  • O. Krishtal
  • Medicine, Chemistry
  • Neuropharmacology
  • 1 July 2015
The history of ASICs began in 1980 with unexpected observation. The concept of highly selective Na(+) current gated by specific receptors for protons was not easily accepted. It took 16 years to getExpand
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G-protein-independent modulation of P-type calcium channels by μ-opioids in Purkinje neurons of rat
P-type calcium channels play a key role in the synaptic transmission between mammalian central neurons since a major part of calcium entering pre-synaptic terminals is delivered via these channels.Expand
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Surface charge impact in low-magnesium model of seizure in rat hippocampus.
Putative mechanisms of induction and maintenance of seizure-like activity (SLA) in the low Mg(2+) model of seizures are: facilitation of NMDA receptors and decreased surface charge screening nearExpand
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