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Molecular Targets for Antiviral Agents
TLDR
For many years virus diseases have been considered as intractable to selective antiviral chemotherapy because the replicative cycle of the virus was assumed to be too closely interwoven with normal cell metabolism so that any attempt to suppress virus reproduction would be doomed to kill the uninfected cell as well.
The pharmacology of the veratrum alkaloids.
STUDIES ON VERATRUM ALKALOIDS
TLDR
The hitherto known antagonists of epinephrine, which abolish or prevent its vasopressor action, are devoid of the property of veratramine, when they are subjected to study under identical conditions.
Clinical Studies on Veratrum Alkaloids: I. The Action of Protoveratrine and Veratridine in Hypertension
The action of two pure veratrum alkaloids, veratridine and protoveratrine, in human hypertension is described for the first time. The vasodepressor reflex pathway involved in the response to these
Threshold dose and time course of norepinephrine depletion of the mammalian heart by reserpine.
The heart rate-increasing effect of a challenging dose of 3 mg reserpine given to the heart-lung preparation of the dog is a reliable measure of the cardiac content of intrinsic sympathomimetic
STUDIES ON VERATRUM ALKALOIDS VI. PROTOVERATRINE: ITS COMPARATIVE TOXICITY AND ITS CIRCULATORY ACTION
TLDR
Tachyphylaxis to the cardiodecelerator effect as well as to the depressor effect develops much more readily with protoveratrine than with veratridine, and large dosages of prot overatrine cause release of epinephrine from the suprarenal gland, which is an important element in the vasopressor effect.
STUDIES ON VERATRUM ALKALOIDS I. THE ACTION OF VERATRINE UPON THE ISOLATED MAMMALIAN HEART
TLDR
The cardiac action of non-toxic doses of veratrine was studied in the heart-lung preparation of the dog and an effect upon the heart muscle which, particularly in the failing heart, increases the total output and improves the work of the heart, simultaneously with a decrease in the diastolic ventricular volume.
Veratrum Alkaloids with Antihypertensive Activity
The rational use of certain Veratrum alkaloids in the treatment of hypertension has its scientific origin and pharmacological basis in the observation of von Bezold and Hirt (1867) that, in the
Rudolf Boehm and his school of pharmacologists
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