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A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans.
In the dimorphic fungus Candida albicans, the CHS2 gene encodes a chitin synthase that is expressed preferentially in the hyphal form and the "ura-blaster" protocol described for Saccharomyces, which involves the sequential disruption of multiple alleles by integrative transformation with URA3 as a single selectable marker, was achieved.
Sordarins: A New Class of Antifungals with Selective Inhibition of the Protein Synthesis Elongation Cycle in Yeasts
Experimental results indicate that sordarin analogs exert their antifungal effects by specifically inhibiting the protein synthesis elongation cycle in yeasts but do not affect protein synthesis machinery in mammalian systems.
Inflammatory reactions to staphylococcal protein A in mice.
Mice do not show anaphylactic shock and this may be a function of the class of murine Igs interacting with Protein A, or because in the mouse, unlike other subjects which have been used, histamine does not play a part.
Association between histocompatability antigens (HLA) and nasal carriage of Staphylococcus aureus.
Investigation of the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations--healthy laboratory workers and patients attending an outpatients' clinic found the importance of the analysis of antigen combinations is discussed.
Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The
Novel inhibitors of fungal protein synthesis produced by a strain of Graphium putredinis. Isolation, characterisation and biological properties.
The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described, providing interesting insights into the structure-activity relationships in this series.
Pathogenesis of skin and wound infections. Animal models
Animals models have been developed to investigate skin colonization with pathogens, provide a mechanism for the study of virulence determinants in the infectious process, determine the efficacy of anti-infective agents and investigate pathogens under in vivo conditions.
Hormonal factors in vaginal candidiasis in rats
The hormonal status of rats affected vaginal infection with Candida albicans, which varied in their virulence, which correlated with their ability to produce germ tubes in vitro to a greater extent than washings from other rats.
Experimental staphylococcal infections in newborn mice: inhibition of weight gain as an index of virulence.
The neonatal mouse model was evaluated as an indicator of the virulence of staphylococcal strains freshly isolated from human patients in hospital and the multiplication of organisms in the skin was correlated with the inhibition of normal weight gain.
Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z
An N-acetyl-D-[14C]glucosamine radiolabel incorporation assay has been used to monitor chitin biosynthesis in whole cells of Candida albicans both in vitro and in vivo in two different mouse