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The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.
- J. W. Oldham, L. E. Allred, G. Milo, O. Kindig, C. Capen
- Biology, MedicineToxicology and applied pharmacology
Normal human fibroblasts in vitro were used as a system to examine the cellular effects of potentially toxic compounds and multiple biochemical parameters with ultrastructural and cytotoxicity studies were effective in demonstrating the mechanisms as well as the degree of toxicity induced by these chemical compounds.
Structural and functional properties of adult rat heart myocytes lysed with digitonin.
- R. Altschuld, W. Wenger, +5 authors G. Brierley
- Medicine, BiologyThe Journal of biological chemistry
- 15 November 1985
Since hypercontracture of heart myocytes appears analogous to the formation of contraction bands in situ, these observations may be relevant to the phenomena of oxygen paradox and of Ca2+ paradox in intact myocardial tissue.
Electron microscopy of tissue cultures infected with porcine polioencephalomyelitis virus.
Elemental modifications and polycyclic aromatic hydrocarbon metabolism in human fibroblasts
- R. Hart, F. Daniel, O. Kindig, C. A. Beach, L. Joseph, R. C. Wells
- Chemistry, MedicineEnvironmental health perspectives
- 1 February 1980
The effects of mineral fibers on the metabolism and biochemistry of polycyclic aromatic hydrocarbons were investigated to investigate whether or not these same physical properties are responsible for the purported synergistic interaction between cigarette smoking and asbestos exposure relative to the induction of bronchogenic carcinoma.
Pars Plicata in Equine Recurrent Uveitis
The ultrastructural morphology of the non-pigmented ciliary epithelium and pigmented epithellium of the pars plicata in normal horses and in horses affected with ERU is compared.
Ultrastructural development of hyperosteoidosis in 1,25(OH)2D3-treated rats fed high levels of dietary calcium.
To evaluate the sequential ultrastructural pathogenesis of the increase in osseous tissue and hyperosteoidosis previously demonstrated in rats administered supraphysiologic doses of 1,25(OH)2D3 and…
The role of dietary calcium on the development of soft tissue mineralization due to 1,25-dihydroxyvitamin D3 intoxication in rats
- N. Kirui, S. Weisbrode, O. Kindig
- Chemistry, MedicineVirchows Archiv. B, Cell pathology including…
It is concluded that hypercalcemia may be more important than a direct toxic effect of 1,25-(OH)2D3 per se in the development of l,25-dihydroxyvitamin D3-induced soft tissue mineralization (STM), and the frequency of STM correlated better with the dietary-influenced level of serum calcium rather than dose.
Multiparametric evaluation of the toxic responses of normal human cells treated in vitro with different classes of environmental toxicants.
- L. E. Allred, J. W. Oldham, G. Milo, O. Kindig, C. Capen
- Biology, MedicineJournal of toxicology and environmental health
- 1 July 1982
It is concluded that similarities in survival responses of cells to closely related toxicants may arise frequently through toxic action at different sites within the cells.
Ultrastructural alterations of tissue cultures infected with a pathogenic porcine adenovirus.
Mitochondrial enzyme retention by irreversibly damaged rectangular isolated adult rat heart myocytes.
- W. Wenger, M. Murphy, O. Kindig, C. Capen, G. Brierley, R. Altschuld
- Biology, MedicineLife sciences
- 4 November 1985
The present study establishes that the supposition that irreversibly hypoxic injury must cause mitochondrial enzyme efflux and hypercontracture is invalid and is established that this supposition is invalid.