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Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor. Expand
Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells.
The data suggest that the CaR activates MAPK through PKC, presumably through Gq/11-mediated activation of PI-PLC, as well as through G(i)- and PTK-dependent pathway(s) in bovine parathyroid and HEKCaR cells and indicate the importance of MAPK in cPLA2 activation. Expand
A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor.
Gain-of-function mutations in the calcium-sensing receptor are associated with a familial syndrome of hypocalcemia with hypercalciuria that needs to be distinguished from hypoparathyroidism. Expand
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
The findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface. Expand
Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism.
There is a variable, but substantial, reduction in the immunoreactivity of the Ca2+o-sensing receptor protein in both parathyroid adenomas and uremic hyperparathyroidism, as assessed by immunohistochemistry, that probably results from reduced expression of the receptor protein and may contribute to the increase in the set-point often observed in these patients. Expand
Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines.
Whether the MCF-7 and MDA-MB-231 human breast cancer cell lines express the CaR and whether CaR agonists modulate PTHrP secretion is investigated, which could potentially participate in a vicious cycle in which PTHRP-induced bone resorption raises the levels of Ca2+(o) and TGFbeta within the bony microenvironment, which then act in concert to evoke further P THrP release and worsening osteolysis. Expand
Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells.
It is demonstrated that mutations which enhance or reduce the responsiveness of the CaR to [Ca2+]o cause the disorders ADH, FBH, and NSHPT, respectively. Expand
The Ca2+-sensing receptor: a target for polyamines.
  • S. Quinn, C. Ye, +4 authors E. Brown
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 1 October 1997
Data suggest that polyamines could be effective agonists for the CaR, and several tissues, including the brain, may use theCaR as a target for the actions of spermine and other endogenous polycationic agonists. Expand
Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation.
Findings indicate that activation of the CaR transactivates the EGFR, but not the PDGFR, leading to phosphorylation of ERK1/2 and resultant PTHrP secretion, although CaR-EGFR-ERK might not be the only signaling pathway for PTHRP secretion. Expand
Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation
It is demonstrated that a missense mutation (Glu128Ala) in this gene causes familial hypocalcaemia in affected members of one family, and this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcemia in patients heterozygous for such a mutation. Expand