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Redox Biology of Respiratory Viral Infections
TLDR
Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage. Expand
Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis
TLDR
Current knowledge of the metabolic changes that occur during HSC activation are summarized with a particular focus on the retinol and lipid metabolism, the central carbon metabolism, and associated redox or stress-related signaling pathways. Expand
Prokaryotic Expression, Purification and Immunogenicity in Rabbits of the Small Antigen of Hepatitis Delta Virus
TLDR
A set of reproducible methods for the expression in E. coli of His-tagged small antigen of HDV (S-HDAg), its purification, and production of polyclonal anti-S- HDAg antibodies in rabbits are described. Expand
Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype
TLDR
It is demonstrated that polyamine metabolism is tightly linked to EMT and differentiation of liver epithelial cells and that spermidine is a key regulator of hepatocyte differentiation. Expand
Data on synthesis of methylene bisphosphonates and screening of their inhibitory activity towards HIV reverse transcriptase
TLDR
Chemical synthesis of eleven methylenebisphosphonates with their NMR and HRMS analysis synthesized via five different ways are presented and structure–activity relationships and inhibitory activity data of synthesized BPs are presented. Expand
Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity.
TLDR
The impact of the thymidine analog mutations (TAM) on the activity of bisphosphonates, as well as some structural features of the BPs, allowing them to maintain the inhibitory activity on the enzyme resistant to nucleoside analog therapy. Expand
On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge
TLDR
Investigation of the interaction of carbonyl diphosphonic acid with hydroxylamine clearly demonstrates that it is impossible to isolate oxime within the pH range 2–12, while only cyanophosphonic and phosphoric acids are the products of the fast proceeding Beckmann-like fragmentation. Expand
RNA-Dependent RNA Polymerase Activity of HCV NS5B Protein Is Modulated by Glutathionylation
TLDR
Using antibodies against glutathionylated proteins, it is shown that the recombinant NS5B protein of 1b or 2a genotypes, expressed in E.coli, contain glytathione residues, and possible redox modifications of NS5 B protein as a link between these events are explored. Expand
Oxidative Stress in Hepatitis C Infection
TLDR
The molecular mechanisms by which HCV modulates cellular systems that generate or eliminate oxidative stress and control cellular redox homeostasis are described and the impact of an altered cellularRedoxHomeostasis on HCV replication, as well as the on the course and outcome of liver fibrosis and hepatocarcinogenesis are discussed. Expand
Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation
TLDR
Redox-sensitive posttranslational modifications of HCV NS5B and other proteins merit a more detailed investigation and analysis of their role(s) in the virus life cycle and associated pathogenesis. Expand