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Solid lipid nanoparticles for parenteral drug delivery.
Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future.
Natural products as antiparasitic drugs
This review shows that many novel lead structures in natural products, including plant-derived alkaloids, terpenes and phenolics, have severe chemico-physical drawbacks such as poor solubility and here, innovative drug formulations and carrier systems might help.
Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use
Pantethine rescues a Drosophila model for pantothenate kinase–associated neurodegeneration
The data suggest that pantethine may serve as a starting point to develop a possible treatment for PKAN, and show evidence for the presence of a de novo CoA biosynthesis pathway in which Pantethine is used as a precursor compound.
Pharmacological profile of extracts of Pelargonium sidoides and their constituents.
- H. Kolodziej, O. Kayser, O. Radtke, A. Kiderlen, E. Koch
- BiologyPhytomedicine : international journal of…
The results indicate that P. sidoides extracts may well possess antimycobacterial activity as claimed in traditional uses and provide for a rationale basis of the utilization of EPs 7630 in the treatment of respiratory tract infections.
Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme.
The antibacterial activity of extracts and isolated constituents of Pelargonium sidoides and PelargonIUM reniforme and Geraniaceae, plant species used in folk medicine by the Southern African native population, was evaluated and provides for a rational basis of the traditional use of the titled Pel Argonium species.
Immunomodulatory principles of Pelargonium sidoides
Data indicate that the samples acted indirectly on Leishmania parasites, possibly by activating leishmanicidal macrophage functions, and provide a rational basis for both the traditional and the present utilization of P. sidoides in the claimed conditions.
The impact of nanobiotechnology on the development of new drug delivery systems.
- O. Kayser, A. Lemke, N. Hernández-Trejo
- Biology, EngineeringCurrent pharmaceutical biotechnology
- 31 January 2005
This review discusses nanoparticular drug carrier systems with the exception of liposomes used today, and what the potential and limitations of nanoparticles in the field of pharmaceutical biotechnology are.
Lipid-Drug-Conjugate (LDC) Nanoparticles as Novel Carrier System for the Hydrophilic Antitrypanosomal Drug Diminazenediaceturate
- C. Olbrich, A. Gessner, O. Kayser, R. Müller
- Biology, ChemistryJournal of drug targeting
- 1 January 2002
Results provide a first basis of using LDC-polysorbate 80 nanoparticles for brain delivery of diminazene to treat second stage human African trypanosomiasis (HAT).