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In‐depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS‐stimulated endothelial cells
TLDR
This study provides the first in‐depth analysis of the LPS‐induced secretome in human endothelial cells, and a proposed 19 new biomarker candidates for sepsis, including moesin are proposed.
Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity
TLDR
It is proposed that HDAC6 and ERK1 may form a positive feed-forward loop, which might play a role in cancer.
Role of moesin in HMGB1-stimulated severe inflammatory responses.
TLDR
It is demonstrated that the HMGB1-RAGE-moesin axis can elicit severe inflammatory responses, suggesting it to be a potential target for the development of diagnostics and therapeutics for sepsis.
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α
TLDR
It is suggested that deacetylation and upregulation of ERα by Sirt6 in preosteoclasts prevent bone loss by inhibiting osteoclast-mediated bone resorption and may provide a new therapeutic approach to attenuate osteoporosis in older or postmenopausal patients.
A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
TLDR
The findings indicate that thelephoric acid may be a novel, non-specific CYP inhibitor, suggesting that it could replace SKF-525A in inhibitory studies designed to investigate the effects of CYP enzymes on the metabolism of given compounds.
Global phosphoproteomic analysis of Daphnia pulex reveals evolutionary conservation of Ser/Thr/Tyr phosphorylation.
TLDR
The first global screening of phosphoproteins and their sites of phosphorylation in D. pulex proteins and the predicted biological and functional roles of these phosphorylations are reported.
Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics
TLDR
Spermidine synthase was significantly increased depending on the cancer stage, confirming the possibility of using SRM as a biomarker for prognosis and prediction of advanced PCa.
Global analysis of phosphoproteome dynamics in embryonic development of zebrafish (Danio rerio)
TLDR
This work identifies 3500 nonredundant phosphorylation sites on 2166 phosphoproteins and quantified 1564 phosphoprotein clusters in developing embryos of zebrafish embryos, which is believed to be the largest dataset of phosphiproteins in zebra fish embryos.
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