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  • A P Davies, O. J. Billington, Timothy D McHugh, Denis Anthony Mitchison, Stephen Gillespie
  • Biology, Medicine
  • Journal of clinical microbiology
  • 2000 (First Published: 1 October 2000)
  • Mycobacterium tuberculosis converts pyrazinamide to its active form by using the enzyme pyrazinamidase. This enzyme is coded for on the pncA gene, and mutations in the pncA gene result in absence ofContinue Reading
  • L Kent, Timothy D McHugh, O. J. Billington, Jeremy W. Dale, Stephen Gillespie
  • Medicine, Biology
  • Journal of clinical microbiology
  • 1995 (First Published: 1 September 1995)
  • The insertion sequence IS6110 has an important role in diagnostic PCR and typing of Mycobacterium tuberculosis. We have evaluated a one-tube nested PCR which detects IS6110. Positive results wereContinue Reading
  • Timothy D McHugh, Cassie F Pope, +5 authors Stephen Gillespie
  • Medicine
  • Journal of medical microbiology
  • 2004 (First Published: 1 December 2004)
  • Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis ofContinue Reading
  • A P Davies, L E Newport, O. J. Billington, Stephen Gillespie
  • Medicine
  • The Journal of infection
  • 1999 (First Published: 1 November 1999)
  • OBJECTIVES To audit the time taken to obtain laboratory confirmation of infection with Mycobacterium tuberculosis using in-house methods of polymerase chain reaction (PCR) and culture and referral toContinue Reading
  • A P Davies, O. J. Billington, Barbara A Bannister, William R. C. Weir, Timothy D McHugh, Stephen Gillespie
  • Medicine
  • The Journal of infection
  • 2000 (First Published: 1 September 2000)
  • OBJECTIVES We report the cases of two patients, brother and sister, both with pulmonary tuberculosis. Both patients complied poorly with treatment. One developed multi-drug resistant disease, whilstContinue Reading
  • Stephen Gillespie, O. J. Billington, Aodhán Breathnach, Timothy D McHugh
  • Biology, Medicine
  • Microbial drug resistance
  • 2002 (First Published: 1 December 2002)
  • Recent studies have shown a difference in the genotype of resistant bacteria following passage in animals compared to those passaged in vitro. This suggests that organisms rapidly adapt to theirContinue Reading