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Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C… Expand
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-genome… Expand
Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasm of the pancreas
Background: Synchronous occurrence of intraductal papillary mucinous neoplasm (IPMN) and ductal carcinoma of the pancreas has been reported. Branch duct IPMNs with lower likelihood of malignancy are… Expand
Application of sentinel node biopsy to gastric cancer surgery.
BACKGROUND Sentinel node (SN) biopsy has been tried in the management of a variety of cancers with the hope that it would eliminate many unnecessary lymph node dissections, resulting in less… Expand
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
- A. Fujimoto, Mayuko Furuta, +35 authors H. Nakagawa
- Biology, Medicine
- Nature communications
- 30 January 2015
Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying biliary… Expand
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study.
We have previously shown that sialyl Lewisx antigen (sLex) (NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAC-R) has an important functional role in defining the invasion and metastasis of human… Expand
Factors affecting the prognosis of patients with esophageal cancer undergoing salvage surgery after definitive chemoradiotherapy
Although salvage surgery after definitive chemoradiotherapy (CRT) is common, the safety and indication has not yet been established.
Preoperative Indications for Extended Pancreatectomy for Locally Advanced Pancreas Cancer Involving the Portal Vein
This retrospective study attempted to determine the indications for extended pancreatectomy for locally advanced carcinoma of the pancreas, in terms of postoperative prognosis. An extended… Expand
Total Gastrectomy With Dissection of Lymph Nodes Along the Splenic Artery: A Pancreas-Preserving Method
Background: In Japan, the tail and body of the pancreas are generally removed for dissection of lymph nodes along the splenic artery. A new pancreas-preserving method was developed to decrease the… Expand
Significance of the resection of ovarian metastasis from colorectal cancers
The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3–8% of CRC patients, and the prognosis for patients is very poor. We assessed the clinicopathological… Expand