8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.
- M. Shamim, D. Ukena, W. Padgett, O. Hong, J. Daly
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 March 1988
A series of 1,3-dipropylxanthines were prepared with a variety of substituents at the 8-position. These included 8-aryl and 8-cycloalkyl groups. Polar carboxylate and carboxamide moieties were… Expand
Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.
- J. Daly, O. Hong, W. Padgett, M. Shamim, K. Jacobson, D. Ukena
- Chemistry, Medicine
- Biochemical pharmacology
- 15 February 1988
A variety of non-xanthine heterocycles were found to be antagonists of binding of [3H]phenylisopropyladenosine to rat brain A1-adenosine receptors and of activation of adenylate cyclase via… Expand
Modulation of morphine-induced EEG and behavioral effects by dynorphin A-(1-13) in non-tolerant and morphine-tolerant rats
The purpose of the present study was to assess effects of dynorphin A-(1-13) on morphine-induced changes in electroencephalographic (EEG) spectral power and morphine-induced suppression of slow-wave… Expand
Intracerebroventricular morphine produces diuresis 24 h after previous dynorphin/morphine treatment.
The effect of dynorphin A-(1-13) on morphine-induced urine output was studied in the rat. The previous simultaneous intracerebroventricular (i.c.v.) injection of dynorphin (20 micrograms/rat) and… Expand
Differential tolerance to repeated daily injections of N-allylnormetazocine and its enantiomers in the rat
This study was designed to compare the development of tolerance to the effects of N-allylnormetazocine (SKF-10,047) and its enantiomers on the EEG and on behavior. Adult female Sprague-Dawley rats… Expand
Repeated injections of N-allyl-normetazocine (sigma opioid agonist): Effects on EEG and behavior in the rat
N 6‐Substituted 9‐methyladenines: A new class of adenosine receptor antagonists
A series of 15 N 6‐substituted 9‐methyladenines have been assessed as antagonists of A2‐adenosine receptor‐mediated stimulation of adenylate cyclase in membranes of human platelets and rat PC12 cells… Expand
Suppression of PCP-induced behavioral arousal in the rat by yohimbine pretreatment.
- K. Byron, G. Young, N. Khazan, O. Hong
- Psychology, Medicine
- European journal of pharmacology
- 5 November 1985
The ability of yohimbine pretreatment to block PCP-induced increases in general motor behavior and head bobbing was assessed in adult female Sprague-Dawley rats. PCP-induced (5 mg/kg i.p.) increases… Expand
Bidirectional cross-tolerance between methadone (mu)- and ethylketocyclazocine (kappa)-tolerant rats.
Our laboratory previously reported on unidirectional cross-tolerance between morphine and methadone, both mu opioid agonists, and between morphine and ethylketocyclazocine (EKC), the latter being a… Expand