eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies
- L. BoussemartHélène Malka-Mahieu S. Vagner
- 27 July 2014
Biology, Medicine
EIF4F not only appears to be an indicator of both innate and acquired resistance but also is a promising therapeutic target that may overcome most of the resistance mechanisms arising in BRAF(V600)-mutant cancers.
Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
- T. Duarte-SallesS. Misra L. Beretta
- 23 June 2016
Medicine
The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis.
High tie in anterior resection for rectal cancer confers no increased risk of anastomotic leakage
- M. RutegårdO. HemmingssonP. MatthiessenJ. Rutegård
- 1 January 2012
Medicine
This population‐based study was carried out to evaluate the independent association between a high arterial ligation and anastomotic leakage in anterior resection for rectal cancer.
Association of Physical Activity and Risk of Hepatobiliary Cancers: A Multinational Cohort Study
- S. BaumeisterS. Schlesinger Leitzmann
- 2018
Medicine
ASNA-1 activity modulates sensitivity to cisplatin.
- O. HemmingssonG. KaoM. StillP. Naredi
- 15 December 2010
Biology, Medicine
The nematode Caenorhabditis elegans can be used to characterize cisplatin resistance mechanisms, and it is suggested that rationally designed drugs against ASNA-1 can sensitize cancer cells to cisPlatin.
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
- D. HughesT. Duarte-Salles M. Jenab
- 1 August 2016
Medicine, Environmental Science
Findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
Treatment patterns and survival in patients with hepatocellular carcinoma in the Swedish national registry SweLiv
- M. HenrikssonB. Björnsson P. Sandström
- 20 November 2019
Medicine
This study aimed to describe treatment patterns and survival outcomes in patients diagnosed with HCC using a national maintained database.
Post cholecystectomy bile duct injury: early, intermediate or late repair with hepaticojejunostomy - an E-AHPBA multi-center study.
- J. RystedtJ. Kleeff K. Zieniewicz
- 1 December 2019
Medicine
Short-course neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer: A multicenter randomized phase-II trial (NORPACT-1).
- K. LaboriS. Bratlie K. Lassen
- 10 June 2023
Medicine
The results do not support neoadjuvant chemotherapy as standard of care for patients with resectable pancreatic head cancer, and future trials should incorporate a biomarker-based design.
Excision and suture in the midline versus Karydakis flap surgery for pilonidal sinus: randomized clinical trial
- O. HemmingssonFelix BinnermarkChristoffer OdenstenM. RutegårdK. FranklinM. Haapamäki
- 8 March 2022
Medicine
Karydakis flap surgery for pilonidal sinus disease led to a shorter wound healing time than excision and suture in the midline but no difference in recurrence rates.
...
...