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Anti-proliferative, in vitro antioxidant, and cellular antioxidant activities of the leaf extracts from Polygonum minus Huds: Effects of solvent polarity
ABSTRACT The present study reports the antioxidant and anti-proliferative activities of Polygonum minus leaf extracts obtained through sequential extraction using four solvents of varying polarities… Expand
IgA binding lectins isolated from distinct Artocarpus species demonstrate differential specificity.
The data provide evidence on the differential specificity of IgA binding lectins isolated from seeds of similar as well as distinct Artocarpus species and selectively precipitating human serum IgA1 and colostral sIgA but not IgA2, IgD, IgG and IgM. Expand
Patients with nasopharyngeal carcinoma demonstrate enhanced serum and tissue ceruloplasmin expression.
- S. Doustjalali, R. Yusof, G. Govindasamy, A. Bustam, B. Pillay, O. Hashim
- The journal of medical investigation : JMI
The proteomics approach was adopted to study the simultaneous expression of serum proteins in patients with nasopharyngeal carcinoma and it was demonstrated that the serum high abundance 2-DE protein profiles of NPC patients were generally similar to that of the controls, with exception of the ceruloplasmin (CPL) spots, which showed higher expression. Expand
Expression of high‐abundance proteins in sera of patients with endometrial and cervical cancers: Analysis using 2‐DE with silver staining and lectin detection methods
The expression of high‐abundance serum proteins in newly diagnosed patients with endometrial adenocarcinoma, squamous cell cervical carcinoma (SCCa) and cervical adenOCarcinomas (ACCa) was analyzed by subjecting serum samples to 2‐DE followed by image analysis of the silver‐stained protein profiles. Expand
Aberrant proteins in the saliva of patients with oral squamous cell carcinoma
The differently expressed saliva proteins may be useful complementary biomarkers for the early detection and/or monitoring of OSCC, although this requires validation in clinically representative populations. Expand
Aberrant expression of acute‐phase reactant proteins in sera and breast lesions of patients with malignant and benign breast tumors
The aberrant expression of the serum acute‐phase proteins of patients with BC and FDB was confirmed by competitive enzyme‐linked immunosorbent assay (ELISA) and similar altered proteins expression was also observed from immunohistochemical studies of malignant and benign breast lesions of the respective patients performed using antisera to the aberrantly expressed proteins. Expand
Lectin‐based electrophoretic analysis of the expression of the 35 kDa inter‐α‐trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies
The lectin‐based electrophoretic bioanalytical method adopted in the present study may be used to assess the physiological relevance of ITIH4 fragmentation and its correlation with different malignancies, their stages and progression. Expand
Identification of potential complementary serum biomarkers to differentiate prostate cancer from benign prostatic hyperplasia using gel‐ and lectin‐based proteomics analyses
The data are suggestive of the potential use of the serum proteins as complementary biomarkers to effectively discriminate PCa from BPH, although this requires further extensive validation on clinically representative populations. Expand
Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins.
- M. Gabrielsen, P. S. Abdul-Rahman, S. Othman, O. Hashim, R. Cogdell
- Chemistry, Medicine
- Acta crystallographica. Section F, Structural…
- 1 June 2014
Galactose- binding and mannose-binding lectins from the champedak fruit exhibit useful potential clinical applications and their complete sequences and crystal structures are presented here, together with details of sugar binding. Expand
A High-Yield Two-Hour Protocol for Extraction of Human Hair Shaft Proteins
- Sing Ying Wong, C. C. Lee, A. Ashrafzadeh, S. M. Junit, Nazirahanie Abrahim, O. Hashim
- Biology, Medicine
- PloS one
- 14 October 2016
A rapid extraction protocol for hair shaft protein using alkaline-based buffer is developed, reducing the extraction time from at least a day to less than two hours and showed a protein recovery of 47.3 ± 3.72%. Expand