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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of theExpand
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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
BACKGROUND Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide aExpand
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Significance We provide a comprehensive catalog of novel genetic variants influencing gene expression and metabolic phenotypes in human pancreatic islets. The data also show that the path fromExpand
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A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global geneExpand
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Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes
To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individualsExpand
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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetesExpand
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Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
Aims/hypothesisReduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencingExpand
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Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
Ratting Out a Diabetes Gene Inbred animals with inherited susceptibility to disease can be especially informative regarding pathogenetic mechanisms because they carry naturally occurring geneticExpand
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TCF7L2 is a master regulator of insulin production and processing
Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants inExpand
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Tissue-specific alternative splicing of TCF7L2
Common variants in the transcription factor 7-like 2 (TCF7L2) gene have been identified as the strongest genetic risk factors for type 2 diabetes (T2D). However, the mechanisms by which theseExpand
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