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Microsomal N-glucuronidation of nicotine and cotinine: human hepatic interindividual, human intertissue, and interspecies hepatic variation.
  • O. Ghosheh, E. Hawes
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 December 2002
Two of the abundant conjugates of human nicotine metabolism result from the N-glucuronidation of S-(-)-nicotine and S-(-)-cotinine, transformations we recently demonstrated in liver microsomes. WeExpand
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N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases.
  • O. Ghosheh, E. Hawes
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 2002
Two predominant human glucuronide metabolites of nicotine result from pyridine nitrogen atom conjugation. The present objectives included determination of the kinetics of formation of S(-)-cotinineExpand
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Formation of the quaternary ammonium-linked glucuronide of nicotine in human liver microsomes: identification and stereoselectivity in the kinetics.
The formation of the N1-glucuronide metabolite of each nicotine enantiomer was studied in pooled human liver microsomes (n = 6). The metabolite formed from natural S(-)-nicotine was identified byExpand
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Quaternary ammonium-linked glucuronidation of 1-substituted imidazoles by liver microsomes: interspecies differences and structure-metabolism relationships.
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. TheExpand
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Total Cotinine in Plasma: A Stable Biomarker for Exposure to Tobacco Smoke
Determination of plasma cotinine concentration is the predominant assay employed to quantify smoking and exposure to environmental tobacco smoke in epidemiological studies. However, cotinine isExpand
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MICROSOMAL NGLUCURONIDATION NGLUCURONIDATION NGLUCURONIDATION OF NICOTINE AND COTININE : HUMAN HEPATIC INTERINDIVIDUAL , HUMAN INTERTISSUE , AND INTERSPECIES HEPATIC VARIATION
Two of the abundant conjugates of human nicotine metabolism result from the N-glucuronidation of S-( )-nicotine and S-( )-cotinine, transformations we recently demonstrated in liver microsomes. WeExpand