Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer’s disease
- E. Ognibene, S. Middei, G. Laviola
- Biology, PsychologyBehavioural Brain Research
- 30 January 2005
Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties.
- O. Ghirardi, P. Lo Giudice, P. Carminati
- Medicine, BiologyAnticancer Research
- 1 July 2005
ALC is effective in the prevention and treatment of chronic OHP-induced peripheral neurotoxicity in an experimental rat model and indicates that ALC does not interfere with the antitumor effects of OHP.
The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice
- E. Ognibene, W. Adriani, G. Laviola
- Biology, PsychologyProgress in Neuro-psychopharmacology and…
- 1 July 2008
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
- P. Minetti, M. Tinti, G. Tarzia
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 October 2005
Two types of adenosine receptor ligands were designed, i.e., 9H-purine and 1H-imidazo[4,5-c]pyridines, to obtain selective A(2A) antagonists, and we report here their synthesis and binding affinities…
Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats
- W. Adriani, M. Rea, G. Laviola
- Biology, PsychologyPsychopharmacology
- 8 May 2004
Present data suggest that ALC, a drug devoid of psychostimulant properties, may have some beneficial effects in the treatment of ADHD children.
Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man.
- G. Segre, E. Bianchi, M. Corsi, S. D'Iddio, O. Ghirardi, F. Maccari
- Medicine, BiologyArzneimittel-Forschung
- 1 December 1988
The results could indicate the presence of saturation phenomena in the absorption process for the oral doses used, and suggest the use of new forms of administration (slow-release) for carnitine and acetyl-carnitine.
ST 1535: a preferential A2A adenosine receptor antagonist.
- M. Stasi, F. Borsini, P. Carminati
- Biology, MedicineInternational Journal of Neuropsychopharmacology
- 1 October 2006
A preferential A2A adenosine antagonist, ST 1535, with long-lasting pharmacodynamic effects is described, which competitively antagonizes the effects of the A1 adenosines agonist CHA on cAMP and potentiates L-dopa effects in reducing haloperidol-induced catalepsy.
Spatial memory and NGF levels in aged rats: Natural variability and effects of acetyl-l-carnitine treatment
- G. Taglialatela, A. Caprioli, A. Giuliani, O. Ghirardi
- Biology, PsychologyExperimental Gerontology
- 1 September 1996
Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat — study by 13P- and 1H-NMR spectroscopy
- T. Aureli, A. Miccheli, F. Conti
- BiologyBrain Research
- 18 April 1994
30 Days of Continuous Olanzapine Infusion Determines Energy Imbalance, Glucose Intolerance, Insulin Resistance, and Dyslipidemia in Mice
- R. Coccurello, Daniela Brina, A. Moles
- MedicineJournal of Clinical Psychopharmacology
- 1 December 2009
The model of AAP-induced metabolic dysregulation in mice illustrates the development of a cluster of risk factors (metabolic syndrome) and a decrease of energy expenditure (MR) due to chronic OL infusion for the first time.
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