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New PCR Primers for the Screening of NRPS and PKS-I Systems in Actinomycetes: Detection and Distribution of These Biosynthetic Gene Sequences in Major Taxonomic Groups
TLDR
New PCR primers targeted to specifically amplify NRPS and PKS-I gene sequences from actinomycetes observed that the wide distribution of these genes in the well-known productive Streptomyces species is also extended to other minor lineages where in some cases very few bioactive compounds have been identified to date.
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
TLDR
Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
TLDR
Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Actinomycetes: still a source of novel antibiotics.
TLDR
This review will address the discovery of antibiotics from actinomycetes from two different perspectives including an update of the most important antibiotics that have only reached the clinical development in the recent years despite their early discovery, and an overview of themost recent classes of antibiotics described from 2006 to 2017 in the framework of the different strategies employed to untap novel compounds previously overlooked with traditional approaches.
The re-emerging role of microbial natural products in antibiotic discovery
TLDR
Different innovative approaches are defining a completely new framework that is setting the bases for the future discovery of novel chemical scaffolds that should foster a renewed interest in the identification of novel classes of natural product antibiotics from the microbial world.
Current approaches to exploit actinomycetes as a source of novel natural products
TLDR
This work provides an overview of the integrated approaches developed at the former Basic Research Center of Merck Sharp and Dohme in Spain to exploit the diversity and biosynthetic potential of actinomycetes, and includes some examples of those that were successfully applied to the discovery of novel antibiotics.
Patterns of antimicrobial activities from soil actinomycetes isolated under different conditions of pH and salinity
Aims: To evaluate the patterns of the production of antimicrobial compounds by diverse collection of actinomycetes isolated from different geographies under alternative conditions of pH and salinity
Evolution, taxonomy and ecology of the genus Thelebolus in Antarctica
TLDR
An investigation of the biodiversity of some Antarctic lakes revealed that Thelebolus microsporus was one of the preponderant species, suggesting that strains in lake biomats have originated from bird vectors, and a hypothesis on the possible course of evolution in Antarctic Thele bolus is put forward.
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