• Publications
  • Influence
Metabolomics – the link between genotypes and phenotypes
  • O. Fiehn
  • Biology, Medicine
  • Plant Molecular Biology
  • 2004
Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel toExpand
  • 2,895
  • 86
  • Open Access
Proposed minimum reporting standards for chemical analysis
There is a general consensus that supports the need for standardized reporting of metadata or information describing large-scale metabolomics and other functional genomics data sets. Reporting ofExpand
  • 1,815
  • 79
  • Open Access
Metabolite profiling for plant functional genomics
Multiparallel analyses of mRNA and proteins are central to today's functional genomics initiatives. We describe here the use of metabolite profiling as a new tool for a comparative display of geneExpand
  • 1,744
  • 78
  • Open Access
A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis.
The Arabidopsis CBF cold response pathway has a central role in cold acclimation, the process whereby plants increase in freezing tolerance in response to low nonfreezing temperatures. Here weExpand
  • 574
  • 47
  • Open Access
Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry
BackgroundStructure elucidation of unknown small molecules by mass spectrometry is a challenge despite advances in instrumentation. The first crucial step is to obtain correct elemental compositions.Expand
  • 710
  • 40
  • Open Access
Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems.
Metabolic profiling using gas chromatography-mass spectrometry technologies is a technique whose potential in the field of functional genomics is largely untapped. To demonstrate the generalExpand
  • 792
  • 34
  • Open Access
MS-DIAL: Data Independent MS/MS Deconvolution for Comprehensive Metabolome Analysis
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data. We provide an open-sourceExpand
  • 457
  • 34
  • Open Access
FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry.
At least two independent parameters are necessary for compound identification in metabolomics. We have compiled 2 212 electron impact mass spectra and retention indices for quadrupole andExpand
  • 763
  • 29
Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry.
Unknown compounds in polar fractions of Arabidopsis thaliana crude leaf extracts were identified on the basis of calculations of elemental compositions obtained from gas chromatography/low-resolutionExpand
  • 488
  • 28
  • Open Access
The metabolic signature related to high plant growth rate in Arabidopsis thaliana
The decline of available fossil fuel reserves has triggered world-wide efforts to develop alternative energy sources based on plant biomass. Detailed knowledge of the relations of metabolism andExpand
  • 326
  • 25
  • Open Access