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- Publications
- Influence
Metabolomics – the link between genotypes and phenotypes
- O. Fiehn
- Biology, Medicine
- Plant Molecular Biology
- 2004
Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel to… Expand
Proposed minimum reporting standards for chemical analysis
There is a general consensus that supports the need for standardized reporting of metadata or information describing large-scale metabolomics and other functional genomics data sets. Reporting of… Expand
Metabolite profiling for plant functional genomics
- O. Fiehn, J. Kopka, P. Dörmann, T. Altmann, R. Trethewey, L. Willmitzer
- Biology, Medicine
- Nature Biotechnology
- 1 November 2000
Multiparallel analyses of mRNA and proteins are central to today's functional genomics initiatives. We describe here the use of metabolite profiling as a new tool for a comparative display of gene… Expand
A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis.
- D. Cook, S. Fowler, O. Fiehn, M. Thomashow
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 19 October 2004
The Arabidopsis CBF cold response pathway has a central role in cold acclimation, the process whereby plants increase in freezing tolerance in response to low nonfreezing temperatures. Here we… Expand
Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry
BackgroundStructure elucidation of unknown small molecules by mass spectrometry is a challenge despite advances in instrumentation. The first crucial step is to obtain correct elemental compositions.… Expand
Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems.
- U. Roessner, A. Lüdemann, +4 authors A. Fernie
- Medicine
- The Plant cell
- 2001
Metabolic profiling using gas chromatography-mass spectrometry technologies is a technique whose potential in the field of functional genomics is largely untapped. To demonstrate the general… Expand
MS-DIAL: Data Independent MS/MS Deconvolution for Comprehensive Metabolome Analysis
- Hiroshi Tsugawa, Tomas Cajka, +7 authors M. Arita
- Medicine, Biology
- Nature Methods
- 23 April 2015
Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data. We provide an open-source… Expand
FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry.
- T. Kind, G. Wohlgemuth, +4 authors O. Fiehn
- Chemistry, Medicine
- Analytical chemistry
- 15 December 2009
At least two independent parameters are necessary for compound identification in metabolomics. We have compiled 2 212 electron impact mass spectra and retention indices for quadrupole and… Expand
Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry.
- O. Fiehn, J. Kopka, R. Trethewey, L. Willmitzer
- Chemistry, Medicine
- Analytical chemistry
- 7 July 2000
Unknown compounds in polar fractions of Arabidopsis thaliana crude leaf extracts were identified on the basis of calculations of elemental compositions obtained from gas chromatography/low-resolution… Expand
The metabolic signature related to high plant growth rate in Arabidopsis thaliana
- R. Meyer, M. Steinfath, +8 authors T. Altmann
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 13 March 2007
The decline of available fossil fuel reserves has triggered world-wide efforts to develop alternative energy sources based on plant biomass. Detailed knowledge of the relations of metabolism and… Expand