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Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease.
TLDR
The results show that mucosal gluten exposure in patients with celiac disease rapidly elicits high levels of IFN-gamma expression and lower levels of IL-2,IL-4, IL-6, and tumor necrosis factor alpha even in the virtual absence of IL -12.
Duodenal adenomatosis in familial adenomatous polyposis
TLDR
The high incidence and increasing severity of duodenal adenomatosis with age justifies prophylactic examination, and a programme is presented for upper gastrointestinal endoscopic surveillance.
Cholangiocarcinoma in Primary Sclerosing Cholangitis: Risk Factors and Clinical Presentation
TLDR
A high proportion of cholangiocarcinoma cases is diagnosed within the first year after diagnosis of PSC, and a long history of inflammatory bowel disease is a risk factor for CC development.
Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
TLDR
The findings suggest preferential mucosal presentation of gluten-derived peptides by HLA-DQ(alpha 1*0501, beta 1*0201) in CD, which may explain the HLA association.
Duodenal adenomatosis in familial adenomatous polyposis
TLDR
The Spigelman stage worsened significantly (P<0.05) with time from the diagnosis of FAP, which may suggest an increasing risk of carcinoma by time.
Relationship of inflammatory bowel disease and primary sclerosing cholangitis.
TLDR
Most studies have found no differences in epidemiology, pathogenetic factors, clinical findings related to the hepatobiliary disease and prognosis between those who present with PSC alone and those whoPresent with combined PSC and IBD.
Patients with small duct primary sclerosing cholangitis have a favourable long term prognosis
TLDR
Patients with small duct PSC seem to have a good prognosis in terms of survival and development of cholangiocarcinoma.
Features of autoimmune hepatitis in primary sclerosing cholangitis: An evaluation of 114 primary sclerosing cholangitis patients according to a scoring system for the diagnosis of autoimmune hepatitis
TLDR
A modification of the scoring system, in particular by increasing the negative score for histological biliary changes, would improve its potential to discriminate between AIH and PSC.
HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations.
TLDR
The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations and PSC was found to be positively associated to three different HLAclass II haplotypes.
Sclerosing cholangitis in ulcerative colitis.
TLDR
The follow-up study has so far shown that most patients with sclerosing cholangitis remain asymptomatic for a considerable period of time.
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