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Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
These factors have been shown to substantially affect the biodistribution and blood circulation half-life of circulating nanoparticles by reducing the level of nonspecific uptake, delaying opsonization, and increasing the extent of tissue specific accumulation.
Nanocarriers as an emerging platform for cancer therapy.
The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
The potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application is demonstrated and remarkable efficacy and reduced toxicity as measured by mean body weight loss (BWL) in vivo are demonstrated.
Cancer nanomedicine: progress, challenges and opportunities
Novel engineering approaches are discussed that capitalize on the growing understanding of tumour biology and nano–bio interactions to develop more effective nanotherapeutics for cancer patients.
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile,
Microfluidic platform for controlled synthesis of polymeric nanoparticles.
This work used rapid and tunable mixing through hydrodynamic flow focusing in microfluidic channels to control nanoprecipitation of poly(lactic- co-glycolic acid)- b-poly(ethylene glycol) diblock copolymers as a model polymeric biomaterial for drug delivery.
Nanoparticle delivery of cancer drugs.
The various nanoparticles drug delivery platforms and the important concepts involved in nanoparticle drug delivery are discussed and the clinical data on the approved nanoparticle therapeutics as well as the nanotherapeutics under clinical investigation are reviewed.