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Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
- F. Alexis, Eric M. Pridgen, Linda Molnar, O. Farokhzad
- Chemistry, Medicine
- Molecular pharmaceutics
- 1 August 2008
Nanoparticle (NP) drug delivery systems (5−250 nm) have the potential to improve current disease therapies because of their ability to overcome multiple biological barriers and releasing a… Expand
Nanoparticles in Medicine: Therapeutic Applications and Developments
- L. Zhang, F. Gu, J. M. Chan, A. Wang, R. S. Langer, O. Farokhzad
- Clinical pharmacology and therapeutics
- 1 May 2008
Nanotechnology is the understanding and control of matter generally in the 1–100 nm dimension range. The application of nanotechnology to medicine, known as nanomedicine, concerns the use of… Expand
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
- O. Farokhzad, J. Cheng, +5 authors R. Langer
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 18 April 2006
Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents a potentially powerful technology. Using prostate cancer as a model, we report docetaxel… Expand
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.
- N. Bertrand, J. Wu, Xiaoyang Xu, Nazila Kamaly, O. Farokhzad
- Advanced drug delivery reviews
- 1 February 2014
Cancer nanotherapeutics are progressing at a steady rate; research and development in the field has experienced an exponential growth since early 2000's. The path to the commercialization of oncology… Expand
Cancer nanomedicine: progress, challenges and opportunities
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer… Expand
Nanocarriers as an emerging platform for cancer therapy.
- D. Peer, J. Karp, Seungpyo Hong, O. Farokhzad, R. Margalit, R. Langer
- Nature nanotechnology
- 1 December 2007
Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may… Expand
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile,… Expand
Targeted Polymeric Therapeutic Nanoparticles: Design, Development and Clinical Translation
- Nazila Kamaly, Zeyu Xiao, P. Valencia, Aleksandar F. Radovic-Moreno, O. Farokhzad
- 3 July 2012
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such… Expand
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.
- J. Cheng, Benjamin A. Teply, +7 authors O. Farokhzad
- Materials Science, Medicine
- 1 February 2007
Nanoparticle (NP) size has been shown to significantly affect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminated… Expand
Microfluidic platform for controlled synthesis of polymeric nanoparticles.
A central challenge in the development of drug-encapsulated polymeric nanoparticles is the inability to control the mixing processes required for their synthesis resulting in variable nanoparticle… Expand