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Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
Nanoparticle (NP) drug delivery systems (5−250 nm) have the potential to improve current disease therapies because of their ability to overcome multiple biological barriers and releasing aExpand
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Nanoparticles in Medicine: Therapeutic Applications and Developments
Nanotechnology is the understanding and control of matter generally in the 1–100 nm dimension range. The application of nanotechnology to medicine, known as nanomedicine, concerns the use ofExpand
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Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo.
Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents a potentially powerful technology. Using prostate cancer as a model, we report docetaxelExpand
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Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology.
Cancer nanotherapeutics are progressing at a steady rate; research and development in the field has experienced an exponential growth since early 2000's. The path to the commercialization of oncologyExpand
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Cancer nanomedicine: progress, challenges and opportunities
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancerExpand
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Nanocarriers as an emerging platform for cancer therapy.
Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that mayExpand
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Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile,Expand
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Targeted Polymeric Therapeutic Nanoparticles: Design, Development and Clinical Translation
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products suchExpand
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Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.
Nanoparticle (NP) size has been shown to significantly affect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminatedExpand
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Microfluidic platform for controlled synthesis of polymeric nanoparticles.
A central challenge in the development of drug-encapsulated polymeric nanoparticles is the inability to control the mixing processes required for their synthesis resulting in variable nanoparticleExpand
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