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[Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation].
TLDR
The method, based on the use of evenly tritium-labeled peptides, allows the determination of peptide concentrations and the activity of enzymes involved in their degradation on a tg scale of biological samples both in vitro and in vivo.
Natural and hybrid ("chimeric") stable regulatory glyproline peptides.
The Binding of Semax, ACTH 4–10 Heptapeptide, to Plasma Membranes of the Rat Forebrain Basal Nuclei and Its Biodegradation
TLDR
Dipeptidylaminopeptidases are considered to be the main enzymes responsible for Semax biodegradation; they successively cleave Semax to the HFPGP pentapeptide and the PGP tripeptide.
Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain‐derived neurotrophic factor protein in rat basal forebrain
TLDR
Results point to the presence of specific binding sites for Semax in the rat basal forebrain, and indicate that the cognitive effects exerted by Semax might be associated, at least in part, with increased BDNF protein levels in this brain region.
The Heptapeptide SEMAX stimulates BDNF Expression in Different Areas of the Rat Brain in vivo
TLDR
The heptapeptide SEMAX is an analog of the ACTH(4–10) fragment completely devoid of any hormonal activity present in the full-length ACTH molecule and produces a marked nootropic effect if administered at very small doses.
Correction of Long-Lasting Negative Effects of Neonatal Isolation in White Rats Using Semax
TLDR
It was shown that neonatal isolation leads to a delay in physical development, metabolic disturbances, and a decrease in the corticosterone stress response in white rats, and chronic intranasal administration of Semax after termination of the neonatal isolating procedure diminishes the negative effects of neonatal stress.
Neurotropic activity of ACTH7–10PGP, an analog of an ACTH fragment
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