• Publications
  • Influence
Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water
Regulatory requests that marketing authorization holders for chemically synthesized active substances risk assess their medicines for the potential presence of N-nitrosamines has led to a renewed i...
Novel lactam NK1 antagonists with anti-emetic activity.
Callipeltoside a: total synthesis, assignment of the absolute and relative configuration, and evaluation of synthetic analogues.
TLDR
The total synthesis of the novel antitumor agent callipeltoside A, as well as several analogues, is accomplished and allows assignment of the stereochemistry not previously established and the excellent chemo- and regioselectivity highlights the synthetic potential of this new ruthenium catalyzed process.
Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.
TLDR
From this strategy emerged a short, practical synthesis of C-2-epi-hygromycin A, where the utility of a phenol as a nucleophile in the Pd catalyzed glycosylation is demonstrated.
The Lactol Route to Fesoterodine: An Amine-Promoted Friedel–Crafts Alkylation on Commercial Scale
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale
Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.
TLDR
From this strategy emerged a short, practical synthesis of C-2-epi-hygromycin A, where the utility of a phenol as a nucleophile in the Pd catalyzed glycosylation is demonstrated.
NK1 antagonists based on seven membered lactam scaffolds.
...
...