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Potential for the Formation of N-Nitrosamines during the Manufacture of Active Pharmaceutical Ingredients: An Assessment of the Risk Posed by Trace Nitrite in Water
- I. Ashworth, O. Dirat, A. Teasdale, M. Whiting
- Chemistry
- 3 August 2020
Regulatory requests that marketing authorization holders for chemically synthesized active substances risk assess their medicines for the potential presence of N-nitrosamines has led to a renewed i...
Novel lactam NK1 antagonists with anti-emetic activity.
- G. Hollingworth, E. Carlson, C. Swain
- Biology, ChemistryBioorganic & medicinal chemistry letters
- 1 March 2006
Callipeltoside a: total synthesis, assignment of the absolute and relative configuration, and evaluation of synthetic analogues.
- B. Trost, J. Gunzner, O. Dirat, Y. Rhee
- Chemistry, BiologyJournal of the American Chemical Society
- 7 August 2002
TLDR
Callipeltoside A: assignment of absolute and relative configuration by total synthesis.
- B. Trost, O. Dirat, J. Gunzner
- ChemistryAngewandte Chemie
- 1 March 2002
Regioselective synthesis of 4-(2-alkyl-5-methyl-2H-pyrazol-3-yl)-piperidines
- O. Dirat, A. Clipson, D. Shaw
- Chemistry
- 13 March 2006
Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.
TLDR
The Lactol Route to Fesoterodine: An Amine-Promoted Friedel–Crafts Alkylation on Commercial Scale
- O. Dirat, Andrew J. Bibb, Flavien Susanne
- Chemistry
- 1 July 2011
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale…
Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.
TLDR
NK1 antagonists based on seven membered lactam scaffolds.
- J. Elliott, E. Carlson, A. Wheeldon
- Chemistry, BiologyBioorganic & medicinal chemistry letters
- 1 June 2006
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