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Methylomonas paludis sp. nov., the first acid-tolerant member of the genus Methylomonas, from an acidic wetland.
An aerobic methanotrophic bacterium was isolated from an acidic Sphagnum peat bog in north-eastern Russia and designated strain MG30(T) is proposed to classify as representing a novel, acid-tolerant species of the genus Methylomonas. Expand
The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells
MLN4924 disrupts NF-κB activation and induces Bim expression in CLL cells, thereby preventing stroma-mediated resistance and enhancing the antitumor activity of the inhibitors of B-cell receptor (BCR)–associated kinases. Expand
Molecular pathogenesis of chronic lymphocytic leukemia.
Molecules involved in BCR signaling pathways and cytoplasmic pro-survival players probably act in concert to confer resistance to apoptosis, and the role of the B-CLL environment, which includes nurse-like cells and T-cells, cannot be underestimated. Expand
Cardiac non‐Hodgkin's lymphoma: clinical characteristics and trends in survival
The purpose of this study was to describe the clinical characteristics and outcomes in cardiac non‐Hodgkin's lymphoma (NHL).
A new cell morphotype among methane oxidizers: a spiral-shaped obligately microaerophilic methanotroph from northern low-oxygen environments
It is shown that spiral-shaped methanotrophic bacteria do exist in nature but elude isolation by conventional approaches due to the preference for growth under micro-oxic conditions, and the helical cell shape may enable rapid motility of these bacteria in water-saturated, heterogeneous environments with high microbial biofilm content, therefore offering an advantage of fast cell positioning under desired high methane/low oxygen conditions. Expand
Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma
Increased rates of chromosome mis-segregation in DLBCL substantiate inferior outcome and poor prognosis, and it is proposed that targeting CIN would yield superior prognosis and improved response to chemotherapeutic drugs. Expand
Methylovulum psychrotolerans sp. nov., a cold-adapted methanotroph from low-temperature terrestrial environments, and emended description of the genus Methylovulum.
The novel isolates, however, differed from Methylovulum miyakonense HT12T by cell morphology, pigmentation, absence of soluble methane monooxygenase, more active growth at low temperatures, growth over a broader pH range and higher DNA G+C content. Expand
Pro‐apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B‐cell receptor signalling in chronic lymphocytic leukaemia
The data illustrate the pro‐apoptotic function of TP63, provide insights into the mechanisms of BCR‐targeting agents, and establish a rationale for designing novel approaches to induce TP63 in CLL and B‐cell lymphoma are established. Expand
Methylocapsa palsarum sp. nov., a methanotroph isolated from a subArctic discontinuous permafrost ecosystem.
Strain NE2T represents a novel species of the genus Methylocapsa, for which the name MethylOCapsa palsarum sp. Expand
Microbial community composition and methanotroph diversity of a subarctic wetland in Russia
The methanotrophic community composition in lichen-dominated sites of a tundra wetland, therefore, was markedly different from that in boreal Sphagnum peat bogs. Expand