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Maternal Intrauterine Infection, Cytokines, and Brain Damage in the Preterm Newborn
To evaluate the hypothesis that the proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor-α might be the link between prenatal intrauterine infection (IUI) and neonatal brain damage, the… Expand
Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants.
OBJECTIVE This case-control study of chronic lung disease (CLD) evaluated the hypothesis that chorioamnionitis promotes CLD and interacts with other risk factors for CLD, including mechanical… Expand
Schizophrenia and Autism: Both Shared and Disorder-Specific Pathogenesis Via Perinatal Inflammation?
Prenatal exposure to infection and subsequent inflammatory responses have been implicated in the etiology of schizophrenia and autism. In this review, we summarize current evidence from human and… Expand
Systemic inflammation disrupts the developmental program of white matter
Perinatal inflammation is a major risk factor for neurological deficits in preterm infants. Several experimental studies have shown that systemic inflammation can alter the programming of the… Expand
Perinatal infection, inflammation, and retinopathy of prematurity.
The major known risk factors for retinopathy of prematurity (ROP) are extremely low gestational age, exposure to high levels of oxygen early after birth (phase I) and relatively lower oxygen levels… Expand
Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm.
Only sparse information is available about a possible association between antenatal infection outside the brain and subsequent cognitive limitations among preterm infants. Based on published studies,… Expand
White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. The Developmental Epidemiology Network.
OBJECTIVES Because intraventricular hemorrhage (IVH) often precedes the development of sonographically defined white matter damage (WMD) in very preterm infants, we sought to identify the IVH… Expand
Maternal obesity and markers of inflammation in pregnancy.
OBJECTIVES To evaluate whether obesity is associated with changes in pro-inflammatory and immunomodulatory cytokines in pregnancy. METHODS We performed a cross-sectional study using maternal serum… Expand
The road from systems biology to systems medicine
- O. Wolkenhauer, C. Auffray, R. Jaster, Prof. Dr. med. Gustav Steinhoff, O. Dammann
- Sociology, Medicine
- Pediatric Research
- 11 January 2013
As research institutions prepare roadmaps for “systems medicine,” we ask how this differs from applications of systems biology approaches in medicine and what we (should) have learned from about one… Expand
The ELGAN study of the brain and related disorders in extremely low gestational age newborns.
BACKGROUND Extremely low gestational age newborns (ELGANs) are at increased risk for structural and functional brain abnormalities. AIM To identify factors that contribute to brain damage in… Expand