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Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC.
Here we provide the updated version of the guidelines of the European Association for Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update was undertaken by theExpand
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The 118 A > G polymorphism in the human µ‐opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
Background:  Dispositions for genes encoding opioid receptors may explain some variability in morphine efficacy. Experimental studies show that morphine and morphine‐6‐glucuronide are less effectiveExpand
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Nasal administration of opioids for pain management in adults
Background: Nasal administration of opioids may be an alternative route to intravenous, subcutaneous, oral transmucosal, oral or rectal administration in some patients. Key features may beExpand
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Gender differences in drug effects: implications for anesthesiologists
Background:  The gender aspect in pharmacokinetics and pharmacodynamics of anesthetics has attracted little attention. Knowledge of previous work is required to decide if gender‐based differences inExpand
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Clinical pharmacology of methadone for pain
Background: This topical review addresses methadone's pharmacology, its application in malignant and non‐malignant pain conditions, practical issues related to methadone for the treatment of pain andExpand
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Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients
ObjectiveOxycodone is widely used for the treatment of cancer pain, but little is known of its pharmacokinetics in cancer pain patients. The aim of this study was to explore the relationships betweenExpand
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Chronic pain and use of opioids: A population-based pharmacoepidemiological study from the Norwegian Prescription Database and the Nord-Trøndelag Health Study
Summary Three quarters of patients using opioids persistently reported strong or very strong pain despite of the medication. ABSTRACT In previous studies on prescription patterns of opioids, accurateExpand
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Chronic pain: One year prevalence and associated characteristics (the HUNT pain study)
Abstract Background The reported prevalence of chronic pain ranges from 11% to 64%, and although consistently high, the calculated economic burden estimates also vary widely between studies. There isExpand
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Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy
HeadingAbstractObjective. UDP-glucuronosyltransferase (UGT) 2B7 is the major UGT isoform responsible for the 3- and 6-glucuronidation of morphine in humans. Studies in rats have indicated that UGT1A1Expand
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