• Publications
  • Influence
Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
Members of the JAK/STAT proteins, TYK 2, STAT 1, and STAT 4 are present and active in human sperm and their activation by IFN-alpha, IFn-gamma, or IL-12 implicate a role for sperm STAT proteins in fertilization.
Clinical development of microbicides for the prevention of HIV infection.
The HIV/AIDS pandemic continues its spread at a rate of over 15,000 new infections every day and current efforts are aimed at developing intravaginal/intrarectal topical formulations of anti-HIV agents or microbicides to curb the mucosal and perinatal HIV transmission.
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity
  • O. D'cruz, F. Uckun
  • Chemistry, Medicine
    Expert opinion on investigational drugs
  • 1 December 2002
The broad spectrum anticancer activity of metvan together with favourable pharmacodynamic features and lack of toxicity warrants further development of this oxovanadium compound as a new anticancer agent.
Novel Bruton’s tyrosine kinase inhibitors currently in development
Preclinical and early clinical results indicate that Btk inhibitors may be useful in the treatment of leukemias and lymphomas.
Heterogeneity of human sperm surface antigens identified by indirect immunoprecipitation of antisperm antibody bound to biotinylated sperm.
These results indicate that in addition to the recognition of common human sperm surface determinants, distinct sperm surface epitopes are also recognized as foreign by the patient's immune system and may account for some of the clinical manifestations of ASA-mediated infertility.
Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
Improved potency, as well as the lack of mucosal, systemic and reproductive toxicity, means that these compounds have clinical potential as safe, prophylactic contraceptives in addition to their microbicide activity to curb the sexual transmission of HIV.
Distribution of human leukocyte antigen-ABC and -D/DR antigens in the unfixed human testis.
Findings indicate that human testicular germ cells express minimal or no MHC antigens.
Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) as a novel apoptosis-inducing anticancer agent.
Experimental evidence that oxovanadium compounds induce apoptosis in human cancer cells is provided, especially the lead compound VO(Me2-phen)2, which may be useful in the treatment of cancer.