• Publications
  • Influence
Nanoparticles: pharmacological and toxicological significance
There is a pressing need for careful consideration of benefits and side effects of the use of nanoparticles in medicine, and a balanced update of these exciting pharmacological and potentially toxicological developments is provided. Expand
Effect of buffer media composition on the solubility and effective permeability coefficient of ibuprofen.
Despite the high amount ionised, ibuprofen appears to be well absorbed and it can be classified as a highly permeable drug, whose ionisation is substantially changed over the pH range of the buffers. Expand
Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties.
The co-spray dried composite system, which displayed best in vitro deposition characteristics, showed a 2.6-fold increase in respirable fraction in the twin impinger experiments and better dose uniformity compared with the physical mix of micronised powders. Expand
The vaccine adjuvant alum inhibits IL‐12 by promoting PI3 kinase signaling while chitosan does not inhibit IL‐12 and enhances Th1 and Th17 responses
It is shown that aluminium hydroxide, aluminium phosphate, and calcium phosphate adjuvants inhibit the secretion of the Th1 polarizing cytokine, IL‐12 by dendritic cells (DCs), and chitosan is an attractive alternative to alum in adjuvant for vaccines where potent cell‐mediated immunity is required. Expand
Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers.
The release of levamisole hydrochloride from poly-DL-lactide-co-glycolide compacts prepared at 5, 10 and 20% drug loading using two different particle size fractions of drug (90-125 and 125-250Expand
Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices--influence of agitation rate and dissolution medium composition.
The sensitivity of polymer erosion to the degree of agitation may influence the ability of these polymers to give reproducible, agitation-independent release, compared to more rigid non-eroding matrix materials, in the complex hydrodynamic environment of the gastrointestinal tract. Expand
Quantifying drug release from PLGA nanoparticulates.
  • O. Corrigan, Xue Li
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 28 June 2009
The polymer erosion related parameters indicated that increased drug loading accelerated this phase of API release, and small acidic hydrophobic actives such as ketoprofen and indomethacin had a much greater effect on these parameters than the larger hydrophilic more neutral proteins, HSA and ovalbumin. Expand
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation.
Raffinose N PMPs presented better characteristics than trehalose NPMPs in terms of their use for inhalation, since particles with larger surface area resulting in higher fine particle fraction can be produced. Expand
Preparation and characterisation of a range of diclofenac salts.
Characterisation techniques included X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, thermomicroscopy, Karl Fischer titration, FT-IR spectroscopy and elemental analysis, and reasonable correlation was found between the free base melting point and the salt melting point. Expand
Spray drying of budesonide, formoterol fumarate and their composites--I. Physicochemical characterisation.
The micronised drugs on their own and the physical mixtures were crystalline in contrast to the spray dried counterparts which were shown to be amorphous. Expand