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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
The discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, is reported, and properties consistent with a role in diabetes and obesity are described, suggesting that U CP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli.
Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells.
A potential link between fatty acid metabolism and thermogenesis may exist in PPAR-expressing tissues and the involvement of PPARgamma2 in adipose cells in up-regulating UCP-2 gene expression is suggested.
Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during…
- L. Casteilla, O. Champigny, F. Bouillaud, J. Robelin, D. Ricquier
- BiologyThe Biochemical journal
- 1 February 1989
It was demonstrated that UCP mRNA reached its highest level at birth in all bovine adipose tissues studied, except subcutaneous tissue, and a sequence of events for the development of brown adipose cells in vivo is proposed.
Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs.
- O. Champigny, D. Ricquier, O. Blondel, R. Mayers, M. G. Briscoe, B. Holloway
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1991
The data suggest that stimulation of beta 3-adrenergic receptors can reactivate nascent BAT (which has the appearance of white adipose tissue) by increasing expression of the gene coding for uncoupling protein or lead to the recruitment of fully differentiated BAT from preadipocyte precursor cells.
In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and…
Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression.
HIB 1B cells represent a functional system for the study of mechanisms related to brown adipose thermogenesis and beta 3-adrenergic receptors account for approximately 30-40% of catecholamine induced UCP gene stimulation, whereas about 60-70% is stimulated via the classical beta 1/2 adrenergic pathway.
Regulation of UCP gene expression in brown adipocytes differentiated in primary culture. Effects of a new β-adrenoceptor agonist
Distribution of the uncoupling protein 2 mRNA in the mouse brain
The role played by UCP2 in the brain has yet to be fully described, but the pattern of distribution of the transcript suggests that this mitochondrial protein is part of neuronal circuitries controlling neuroendocrine functions, autonomic responses, and the general arousal of the brain.
Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: evidence for diet-induced and cold-induced responses.
This first attempt to determine whether varying nutritional conditions could affect UCP gene expression in brown adipose tissue showed that DIT was dissociated from NST, and increasing the ambient temperature to thermoneutrality suppressed the fall in body temperature as well as the rise in UCP mRNA, which could then be characterized as a cold-induced response.
Leptin and Corticosterone Have Opposite Effects on Food Intake and the Expression of UCP1 mRNA in Brown Adipose Tissue of lepob/lepob Mice.
The interaction effect of leptin and corticosterone on food intake and the expression of uncoupling protein 1 (UCP1) mRNA in interscapular brown adipose tissue (IBAT) confirms the anorectic and orexigenic effects of leptin-corticosterone effects and emphasizes the abilities of leptin to respectively increase and reduce theexpression of UCP1 mRNA in IBAT.