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Association of Ezrin with Intercellular Adhesion Molecule-1 and -2 (ICAM-1 and ICAM-2)
- L. Heiska, K. Alfthan, M. Grönholm, P. Vilja, A. Vaheri, O. Carpén
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 August 1998
An interaction of ezrin is indicated with intercellular adhesion molecule (ICAM)-1, -2, and -3 and a regulatory role of phosphoinositide signaling pathways in regulation of ICAM-ezrin interaction is suggested.
Alpha-actinin revisited: a fresh look at an old player.
Association of intercellular adhesion molecule-1 (ICAM-1) with actin- containing cytoskeleton and alpha-actinin
The cytoskeletal association of intercellular adhesion molecule-1 (ICAM-1, CD54), an integral membrane protein that functions as a counterreceptor for leukocyte integrins, is studied to mediate a charged interaction with alpha-actinin which is not highly dependent on the order of the residues.
Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.
- P. Salmikangas, O. Mykkänen, M. Grönholm, L. Heiska, J. Kere, O. Carpén
- BiologyHuman molecular genetics
- 1 July 1999
A novel 57 kDa cytoskeletal protein, myotilin, which is expressed in skeletal and cardiac muscle, and co-localizes with [alpha]-actinin in the sarcomeric I--bands and directly interacts with [ alpha]-Actinin.
Characterization of human palladin, a microfilament-associated protein.
Human palladin expression was up-regulated in differentiating dendritic cells (DCs), coinciding with major cytoskeletal and morphological alterations and suggest a role for palladin in the assembly of DC cytoskeleton.
Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton.
NF2 protein possesses functional properties of an ERM family member, and interaction between NF2 protein and the actin-containing cytoskeleton was indicated by partial colocalization, by cytochalasin B-induced coclustering, and by retention of NF2protein in the detergent-insoluble fraction.
Myotilin is mutated in limb girdle muscular dystrophy 1A.
A mutation in the myotilin gene in a large North American family of German descent expressing an autosomal dominant form of limb girdle muscular dystrophy (LGMD1A) is identified, predicting the conversion of residue 57 from threonine to isoleucine to C450T missense mutation.
Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies.
- S. Helske, P. Vuorela, O. Carpén, C. Hornig, H. Weich, E. Halmesmäki
- Medicine, BiologyMolecular human reproduction
- 1 February 2001
The results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR.
ICAM-2 redistributed by ezrin as a target for killer cells
A new mechanism of target-cell recognition is revealed: cytotoxic cells recognize adhesion molecules that are already present on normal cells, but in diseased cells are concentrated into a biologically active cell-surface region by cytoskeletal reorganization.
Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease.
Results provide evidence that Batten disease can be classified as a member of lysosomal diseases and biosynthesis and localization of CLN3 protein are elucidated.