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Quantitative proteomics analysis of an ethanol- and a lactate-producing mutant strain of Synechocystis sp. PCC6803
BackgroundThis study aimed at exploring the molecular physiological consequences of a major redirection of carbon flow in so-called cyanobacterial cell factories: quantitative whole-cell proteomicsExpand
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Time-series analysis of the transcriptome and proteome of Escherichia coli upon glucose repression.
Time-series transcript- and protein-profiles were measured upon initiation of carbon catabolite repression in Escherichia coli, in order to investigate the extent of post-transcriptional control inExpand
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Molecular physiology of the dynamic regulation of carbon catabolite repression in Escherichia coli.
We report on the use of the chemostat as an optimal device to create time-invariant conditions that allow accurate sampling for various omics assays in Escherichia coli, in combination with recordingExpand
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Promoter motifs essential to the differential transcription of structural and non-structural genes of the white spot syndrome virus
Chimeric reporter genes were generated comprising nine different promoters of the white spot syndrome virus linked to luciferase, with the aim to compare their transcriptional activities in insectExpand
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UvA-DARE ( Digital Academic Repository ) Quantitative proteomics analysis of an ethanol-and a lactate-producing mutant strain of Synechocystis sp . PCC 6803
Background: This study aimed at exploring the molecular physiological consequences of a major redirection of carbon flow in so-called cyanobacterial cell factories: quantitative whole-cell proteomicsExpand
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Synthetic biology of photosynthesis: redirecting carbon flows toward sustainable bioproduction
In order to develop a strategy to engineer a metabolic module of a microbial species such that it produces a compound of interest, detailed knowledge and understanding of the organisms’ genetic,Expand
Dynamic changes of the Escherichia coli transcriptome and proteome exerted by glucose repression
A system biology approach, including multi-omics analyses (i.e. time-resolved monitoring of mRNA and protein levels) with an advanced culturing method, was applied in order to identifyExpand
Multi-omics analyses of the molecular physiology and biotechnology of Escherichia coli and Synechocystis sp. PCC6803
The main aim of this thesis was to investigate the physiological response of bacteria responding to physiological- and engineered changes in their central carbon metabolism through the application ofExpand