• Publications
  • Influence
Molecular clock is involved in predictive circadian adjustment of renal function
Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes inExpand
  • 193
  • 11
  • Open Access
Circadian regulation of renal function.
Urinary excretion of water and all major electrolytes exhibit robust circadian oscillations. The 24-h periodicity has been well documented for several important determinants of urine formation,Expand
  • 74
  • 6
Dysfunction of epithelial sodium transport: from human to mouse.
The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expressionExpand
  • 102
  • 5
α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism.
Paracrine communication between different parts of the renal tubule is increasingly recognized as an important determinant of renal function. Previous studies have shown that changes in dietaryExpand
  • 44
  • 5
  • Open Access
The circadian clock modulates renal sodium handling.
The circadian clock contributes to the control of BP, but the underlying mechanisms remain unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the circadianExpand
  • 92
  • 4
  • Open Access
Local renal circadian clocks control fluid-electrolyte homeostasis and BP.
The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance and BP control. However, the role of peripheral circadian clocks in these homeostatic mechanismsExpand
  • 59
  • 4
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
Elevated plasma urate levels are associated with metabolic, cardiovascular, and renal diseases. Urate may also form crystals, which can be deposited in joints causing gout and in kidney tubulesExpand
  • 166
  • 3
  • Open Access
Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of its alpha subunit.
The autosomal recessive form of type I pseudohypoaldosteronism (PHA-I) is an inherited salt-losing syndrome resulting from diminution-of-function mutations in the 3 subunits of the epithelial Na+Expand
  • 114
  • 3
  • Open Access
Mouse GLUT9: evidences for a urate uniporter.
GLUT9 (SLC2A9) is a newly described urate transporter whose function, characteristics, and localization have just started to be elucidated. Some transport properties of human GLUT9 have been studiedExpand
  • 82
  • 3
  • Open Access
Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation.
The rate-limiting step of dietary calcium absorption in the intestine requires the brush border calcium entry channel TRPV6. The TRPV6 gene was completely sequenced in 170 renal calcium stoneExpand
  • 59
  • 2