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Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if differentiated cell types can be derived from them and used to assembleExpand
Differential cellular expression of isoforms of inositol 1,4,5‐triphosphate receptors in neurons and glia in brain
Inositol 1,4,5‐trisphosphate receptors (IP3R) are mediators of second messenger‐induced intracellular calcium release. Three isoforms are known to be expressed in brain, but their regionalExpand
Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.
Inositol 1,4,5-trisphosphate (IP3) functions as a second messenger for many neurotransmitters, hormones and growth factors. It causes the release of Ca2+ from intracellular stores by binding toExpand
The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin.
This review is intended to describe the characteristics of the rat models of non-insulin-dependent diabetes induced by neonatal streptozotocin administration (n-STZ models), to sum-up the informationExpand
Cloning, Expression, and Pharmacology of Four Human 5‐Hydroxytryptamine4 Receptor Isoforms Produced by Alternative Splicing in the Carboxyl Terminus
Abstract: We report here the molecular cloning of three new splice variants of the human serotonin 5‐hydroxytryptamine4 (h5‐HT4) receptor, which we named h5‐HT4(b), h5‐HT4(c), and h5‐HT4(d). TheExpand
A Glia-Derived Signal Regulating Neuronal Differentiation
Astrocytes are present in large numbers in the nervous system, are associated with synapses, and propagate ionic signals. Astrocytes influence neuronal physiology by responding to and releasingExpand
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis
A coordinated functional genomics program was implemented to identify secreted polypeptides with therapeutic applications in the treatment of diabetes. Secreted factors were predicted from a diverseExpand
Molecular and functional characterization of a 5‐HT4 receptor cloned from human atrium
5‐Hydroxytryptamine (5‐HT) has been shown to exert positive inotropic, chronotropic, and lusitropic effects and to stimulate the L‐type calcium channel current (I Ca) in human atrial tissue throughExpand
Early appearance of in vivo insulin resistance in adult streptozotocin-injected rats.
Hepatic glucose production and peripheral glucose utilisation were measured in vivo with the euglycaemic-hyperinsulinaemic clamp technique in rats rendered severely diabetics with streptozotocin (45Expand
Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs.
Brown adipose tissue (BAT) is present throughout life in rodents and plays an important role in energy balance. However, whereas BAT is clearly recognizable in the neonates of larger mammalsExpand