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Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus
TLDR
The hemagglutinin structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA, which suggests a path for this H 5N1 virus to gain a foothold in the human population. Expand
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.
TLDR
A glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins. Expand
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.
TLDR
The species barrier, as defined by the receptor specificity preferences of 1918 human viruses compared to likely avian virus progenitors, can be circumvented by changes at only two positions in the HA receptor binding site. Expand
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR
TLDR
Structural and mutagenesis data explain how both receptors bind high-mannose oligosaccharides on enveloped viruses and why only DC-SIGN binds blood group antigens, including those present on microorganisms. Expand
Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens*
TLDR
It is demonstrated that each of these galectins mechanistically differ in their binding to glycans on the microarrays and that these differences are reflected in the determinants required for cell binding and signaling. Expand
Dimeric Galectin-1 Binds with High Affinity to α2,3-Sialylated and Non-sialylated Terminal N-Acetyllactosamine Units on Surface-bound Extended Glycans*
TLDR
It is reported that human recombinant dGal-1 bound preferentially and with high affinity to immobilized extended glycans containing terminal LN sequences on poly-N-acetyllactosamine (PL) sequences, complex-type biantennary N-glycans, or novel chitin-derived glycans modified to contain terminals LN. Expand
Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*
TLDR
It is concluded that Siglec-8 binds preferentially to the sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl, similar to how it binds to other sialic acid-binding lectin 8 ligands. Expand
Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity.
TLDR
Widespread occurrence of these susceptible H5N1 clade 2.2 influenza strains should be considered high-risk, because of their significantly lower threshold for acquiring human receptor specificity and, therefore, warrant increased surveillance and further study. Expand
RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
TLDR
It is suggested that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population. Expand
Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells.
TLDR
The results indicate an endogenous function for DC-expressed MGL in the clearance and tolerance to self-gangliosides, and in the pattern recognition of tumor antigens and foreign glycoproteins derived from helminth parasites. Expand
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