• Publications
  • Influence
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
A mechanism for the regulation of cofilin and hence of actin dynamics in vivo is defined and should play a central role in regulating cell motility and morphogenesis by modulating the stability of act in cytoskeletal structures. Expand
Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release
It is shown that neurons rescued from NGF withdrawal-induced apoptosis by expression of dominant-negative c-Jun do not release cytochrome c from their mitochondria, and neurons injected with Bim antisense oligonucleotides or isolated from Bim(-/-) knockout mice die more slowly after NGF withdraw. Expand
Interplay between components of a novel LIM kinase–slingshot phosphatase complex regulates cofilin
A novel ADF/cofilin phosphoregulatory complex is defined and a new mechanism for the regulation of ADF / cofilin activity in mediating changes to the actin cytoskeleton is suggested. Expand
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
This study identifies the first function of the BMPR-II tail domain and suggests that the deregulation of actin dynamics may contribute to the etiology of PPH. Expand
Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin*
PAK4 also regulates the activity of the protein kinase LIM kinase 1 (LIMK1). Expand
Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension
A direct role for ADF/cofilin is indicated in the generation of the barbed ends that are required for lamellipod extension in response to EGF stimulation. Expand
A role for LIM kinase in cancer invasion
It is found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells, demonstrating its potential as a therapeutic molecular target to decrease metastasis. Expand
Lim kinases, regulators of actin dynamics.
  • O. Bernard
  • Medicine, Biology
  • The international journal of biochemistry & cell…
  • 2007
LIMK1 was shown to be involved in cancer metastasis, while LIMK2 activation promotes cells cycle progression, and Hsp90 regulates the levels of the LIM kinase proteins by promoting their homo-dimerisation and trans-phosphorylation. Expand
Rho-associated coiled-coil kinase (ROCK) signaling and disease
This review focuses on the role of the ROCK-signaling pathways in disease including cancer, which regulate many key cellular functions associated with malignancy, including cell proliferation, motility and viability. Expand
Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity.
Overexpression of Bcl-2 in the neurons provided protection, in a dose-dependent manner, against neurotoxins known to selectively damage dopaminergic neurons, providing ideas for inhibition of neuronal cell death in neurodegenerative diseases and for the development of efficient neuroprotective gene therapy. Expand