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Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
Small heat shock proteins (sHsps) are a family of large and dynamic oligomers highly expressed in long-lived cells of muscle, lens and brain. Several family members are upregulated during stress, andExpand
High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract.
Several human cataracts have been linked to mutations in the gamma crystallin gene. One of these is the aculeiform cataract, which is caused by an R58H mutation in gammaD crystallin. We have shownExpand
Polydispersity of a mammalian chaperone: Mass spectrometry reveals the population of oligomers in αB-crystallin
The quaternary structure of the polydisperse mammalian chaperone αB-crystallin, a member of the small heat-shock protein family, has been investigated by using electrospray mass spectrometry. TheExpand
γN‐crystallin and the evolution of the βγ‐crystallin superfamily in vertebrates
The β and γ crystallins are evolutionarily related families of proteins that make up a large part of the refractive structure of the vertebrate eye lens. Each family has a distinctive gene structureExpand
Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract.
Congenital cataract is a leading cause of visual disability in children. Inherited isolated (non-syndromic) cataract represents a significant proportion of cases and the identification of genesExpand
The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain*
γS-crystallin is a major human lens protein found in the outer region of the eye lens, where the refractive index is low. Because crystallins are not renewed they acquire post-translationalExpand
The structure of avian eye lens δ-crystallin reveals a new fold for a superfamily of oligomeric enzymes
The crystal structure of turkey δ-crystallin, a principal soluble components of the avian lens, has been determined to a resolution of 2.5 Å. It is a tetramer, of 200,000 Mr, with 222 symmetry. TheExpand
Urochordate βγ-Crystallin and the Evolutionary Origin of the Vertebrate Eye Lens
A refracting lens is a key component of our image-forming camera eye; however, its evolutionary origin is unknown because precursor structures appear absent in nonvertebrates [1]. The vertebrateExpand
The stability of human acidic β-crystallin oligomers and hetero-oligomers
Abstract Crystallins are bulk structural proteins of the eye lens that have to last a life time. They gradually become modified with age, denature and form light scattering centres. HighExpand
Urochordate betagamma-crystallin and the evolutionary origin of the vertebrate eye lens.
A refracting lens is a key component of our image-forming camera eye; however, its evolutionary origin is unknown because precursor structures appear absent in nonvertebrates. The vertebrateExpand
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