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Evolution of Sex-Specific Traits through Changes in HOX-Dependent doublesex Expression
Analysis in Drosophila suggests that evolutionary changes in the spatial regulation of the transcription factor doublesex play a key role in the origin, diversification, and loss of sex-specific
Evolutionary history of the Drosophila bipectinata species complex.
Despite the low genetic divergence, species of the Drosophila bipectinata complex show an unusually high degree of morphological differentiation, which underscores the importance of understanding the genetic basis of functional differentiation among closely related species.
Evolution of gene expression in the Drosophila olfactory system.
This work surveyed the entire repertoire of Drosophila odorant receptors (ORs) and odorant-binding proteins (OBPs) expressed in the antennae and found that the evolution of OR and OBP expression was accelerated in D. sechellia, a narrow ecological specialist that feeds on the fruit of Morinda citrifolia, compared both with the genome average in that species and with the rate of OBP evolution in the other species.
Comparative validation of the D. melanogaster modENCODE transcriptome annotation.
The vast majority of elements in the D. melanogaster genome annotation are evolutionarily conserved, indicating that the annotation will be an important springboard for functional genetic testing by the Drosophila community.
Distinct developmental mechanisms underlie the evolutionary diversification of Drosophila sex combs
Phylogenetic analysis shows that similar sex comb morphology in closely related Drosophila species is produced by different cellular mechanisms, suggesting that selection can recruit different cellular processes to produce similar functional solutions.
Highly contiguous assemblies of 101 drosophilid genomes
Oxford Nanopore sequencing is utilized to build an open community resource of high-quality assemblies for 101 lines of 95 drosophilid species encompassing 14 species groups and 35 sub-groups with an average contig N50 of 10.5 Mb and greater than 97% BUSCO completeness in 97/101 assemblies.
A Distalless-responsive enhancer of the Hox gene Sex combs reduced is required for segment- and sex-specific sensory organ development in Drosophila
This work has identified two cis-regulatory elements that control spatially modulated Scr expression within T1 legs and shows that this enhancer functions to integrate Scr into the intrasegmental gene regulatory network, such that Scr serves as a link between leg patterning, sex determination, and sensory organ development.