• Publications
  • Influence
Hydroxylation of aromatic hydrocarbons in the rat.
The absorption and elimination of metoclopramide in three animal species
  • O. Bakke, J. Segura
  • Biology, Chemistry
    The Journal of pharmacy and pharmacology
  • 1 January 1976
The findings in the rabbit and in the dog suggest that the liver plays an active role reducing the systemic availability of unchanged metoclopramide after oral administration, and first order elimination kinetics with short half‐lives and high apparent volumes of distribution were observed.
Comparative pharmacokinetics of theophylline and aminophylline in man.
No significant difference was found in the pharmacokinetic parameters or protein binding with the two preparations, and almost identical concentration-time curves were found for theophylline and aminophyllines in both of the studies.
O-methylation of simple phenols in the rat.
  • O. Bakke
  • Chemistry
    Acta pharmacologica et toxicologica
  • 13 March 2009
There was no correlation between the extent of O-methylation of the simple phenols and their potencies as convulsant agents and the administration of resorcinol, hydroquinone, hydroxyquinol and phloroglucinol.
Drug discontinuations in the United Kingdom and the United States, 1964 to 1983: Issues of safety
Since drugs discontinued while a safety question existed represent only 2% of the new chemical entities introduced, it appears that drugs that reach the market under the prevailing regulatory systems are seldom associated with unacceptable toxicity.
Drug selection in a regulated society: the Norwegian experience.
The impact of regulation on the drug market and the therapeutic armamentarium available for health care in Norway are discussed.