O. Bakke

Publications67
h-index21
Citations1,363
Highly Influential Citations43
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Hydroxylation of aromatic hydrocarbons in the rat.
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Drug safety discontinuations in the United Kingdom, the United States, and Spain from 1974 through 1993: A regulatory perspective
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Urinary Simple Phenols in Rats Fed Diets Containing Different Amounts of Casein and 10% Tyrosine
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The absorption and elimination of metoclopramide in three animal species
  • O. Bakke, J. Segura
  • Biology, Chemistry
    The Journal of pharmacy and pharmacology
  • 1 January 1976
TLDR
The findings in the rabbit and in the dog suggest that the liver plays an active role reducing the systemic availability of unchanged metoclopramide after oral administration, and first order elimination kinetics with short half‐lives and high apparent volumes of distribution were observed.
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Comparative pharmacokinetics of theophylline and aminophylline in man.
TLDR
No significant difference was found in the pharmacokinetic parameters or protein binding with the two preparations, and almost identical concentration-time curves were found for theophylline and aminophyllines in both of the studies.
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Urinary simple phenols in rats fed purified and nonpurified diets.
  • O. Bakke
  • Biology
    The Journal of nutrition
  • 1 June 1969
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Hepatic enzymes, CoASH and long-chain acyl-CoA in subcellular fractions as affected by drugs inducing peroxisomes and smooth endoplasmic reticulum.
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O-methylation of simple phenols in the rat.
  • O. Bakke
  • Chemistry
    Acta pharmacologica et toxicologica
  • 13 March 2009
TLDR
There was no correlation between the extent of O-methylation of the simple phenols and their potencies as convulsant agents and the administration of resorcinol, hydroquinone, hydroxyquinol and phloroglucinol.
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Drug discontinuations in the United Kingdom and the United States, 1964 to 1983: Issues of safety
TLDR
Since drugs discontinued while a safety question existed represent only 2% of the new chemical entities introduced, it appears that drugs that reach the market under the prevailing regulatory systems are seldom associated with unacceptable toxicity.
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Drug selection in a regulated society: the Norwegian experience.
TLDR
The impact of regulation on the drug market and the therapeutic armamentarium available for health care in Norway are discussed.
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