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Toll‐like receptor 3 associates with c‐Src tyrosine kinase on endosomes to initiate antiviral signaling
Double‐stranded RNA (dsRNA) is produced during the replication cycle of most viruses and triggers antiviral immune responses through Toll‐like receptor 3 (TLR3). However, the molecular mechanisms andExpand
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MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
The invariant chain (Ii) is a transmembrane protein that associates with the MHC class II molecules in the endoplasmic reticulum. Expression of Ii in MHC class II-negative CV1 cells showed that itExpand
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Post‐replicative base excision repair in replication foci
Base excision repair (BER) is initiated by a DNA glycosylase and is completed by alternative routes, one of which requires proliferating cell nuclear antigen (PCNA) and other proteins also involvedExpand
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Sorting by the Cytoplasmic Domain of the Amyloid Precursor Protein Binding Receptor SorLA
ABSTRACT SorLA/LR11 (250 kDa) is the largest and most composite member of the Vps10p-domain receptors, a family of type 1 proteins preferentially expressed in neuronal tissue. SorLA binds severalExpand
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Major Histocompatibility Complex Class II-Peptide Complexes Internalize Using a Clathrin- and Dynamin-independent Endocytosis Pathway*
Major histocompatibility complex (MHC) class II molecules (MHC-II) function by binding antigenic peptides and displaying these peptides on the surface of antigen presenting cells (APCs) forExpand
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The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.
The oligomeric complex formed by major histocompatibility complex (MHC) class II alpha and beta chains and invariant chain (Ii) assembles in the endoplasmic reticulum and is then transported via theExpand
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Rab7b controls trafficking from endosomes to the TGN
Rab7b is a recently identified member of the Rab GTPase protein family and has high similarity to Rab7. It has been reported that Rab7b is lysosome associated, that it is involved in monocyticExpand
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Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain
The intracellular transport and location of major histocompatibility complex (MHC) class II molecules and associated invariant chain (Ii) were investigated in a human melanoma cell line. In contrastExpand
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The Leucine-based Sorting Motifs in the Cytoplasmic Domain of the Invariant Chain Are Recognized by the Clathrin Adaptors AP1 and AP2 and their Medium Chains*
Recognition of sorting signals within the cytoplasmic tail of membrane proteins by adaptor protein complexes is a crucial step in membrane protein sorting. The three known adaptor complexes, AP1,Expand
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The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.
The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of endosomes. We have recently found that thisExpand
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